The in Vitro Effect of Penicillin

Cohn, Alfred

doi:10.1001/jama.1944.02850160031008

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Sensitivity Of the Gonococcus To Therapeutic Agents1

Development Of Resistance Of the Gonococcus To Penicillin1

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1944

1963

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Cited by 11 publications

(2 citation statements)

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“…This was noted early (Cohn & Seijo, 1944), as was the fact that the resistance of the gonococcus could be increased 20-to 70-fold in the laboratory by repeated subcultures containing penicillin (Mills, 1949).…”

Section: Sensitivity Of the Gonococcus To Therapeutic Agentsmentioning

confidence: 99%

Treatment Problems of Gonorrhoea

Willcox¹

1961

Obstetrical & Gynecological Survey

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Section: Sensitivity Of the Gonococcus To Therapeutic Agentsmentioning

confidence: 99%

Treatment Problems of Gonorrhoea

Willcox¹

1961

Obstetrical & Gynecological Survey

View full text Add to dashboard Cite

“…It was noted early that different strains of gonococci differed widely in their susceptibility to penicillin (Cohn and Seijo 1944) and that resistance could be increased by repeated sub‐culture in a penicillin environment (Bahn et al 1945 ; Mills 1949). However, the investigations of Lankford (1945), Kenedy and Alfoldy (1947), and Hawkes and Greey (1948) suggested no problem of developing penicillin resistance.…”

Section: Development Of Resistance Of the Gonococcus To Penicillinmentioning

confidence: 99%