The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice

Grau, Cai; Høpsyer, Morten; Overgaard, Jens

doi:10.1016/0360-3016(94)90321-2

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…However, some reports indicate that paclitaxel combined with radiation might not result in any synergistic or additive effects [6–8, 11]. Moreover, both Grau and Osmak reported significant therapeutic loss when combining vincristine with radiation [9, 10]. On the other hand, relapse to cancer treatment is often caused by a subpopulation of drug resistant cancer cells.…”

Section: Discussionmentioning

confidence: 99%

G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy

Sui

Zhang

Xia

et al. 2012

Radiotherapy and Oncology

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Background and Purpose We previously demonstrated that radiation may arrest tumor cells at G2 phase, which in turn prevents the cytotoxicity of antimicrotubule drugs and results in antagonistic interaction between these two modalities. Herein we tested whether G2 abrogators would attenuate the above antagonistic interaction and improve the therapeutic efficacy of combination therapy between radiation and antimicrotubule drugs. Materials and Methods Breast cancer BCap37 and epidermoid carcinoma KB cell lines were administered with radiation, UCN-01 (a model drug of G2 abrogator), paclitaxel or vincristine, alone or in combinations. The antitumor activities of single and combined treatments were analyzed by a series of cytotoxic, apoptosis, cell cycle, morphological and biochemical assays. Results UCN-01 significantly enhanced the cytotoxicity of radiation, antimitotic drugs, and their combined treatments in vitro. Further investigations demonstrated that UCN-01 attenuated radiation-induced G2 arrest, and subsequently repressed the inhibitory effect of radiation on drug-induced mitotic arrest and apoptosis. Conclusions This is the first report demonstrating that G2 checkpoint abrogation represses the inhibitory effect of radiation on antimicrotubule drugs, which may be implicated in cancer combination therapy. Considering that G2 abrogators are under extensive evaluation for cancer treatment, our findings provide valuable information for this class of promising compounds.

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Section: Discussionmentioning

confidence: 99%

G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy

Sui

Zhang

Xia

et al. 2012

Radiotherapy and Oncology

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Combination of γ-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis

Sui

Fan

2005

International Journal of Radiation Oncology*Biology*Physics

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Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation

Pauwels¹,

Wouters

Peeters

et al. 2010

Future Oncol.

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The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.

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The in vivo interaction between vincristine and radiation in a C3H mammary carcinoma and the feet of CDF1 mice

Cited by 3 publications

References 15 publications

G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy

G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapy

Combination of γ-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest and apoptosis

Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation

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