The incidence of aberrant endometrial αvβ3 vitronectin expression in a high risk infertility population: could prolonged GnRH agonist therapy play a role?

Surrey, Eric S.; Minjarez, D.A.; Schoolcraft, William B.

doi:10.1007/s10815-007-9164-3

Cited by 39 publications

(42 citation statements)

References 18 publications

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“…Validation of the VTN DE by real time-qPCR is close to statistical significance (P ¼ 0.051). According to previous studies [7,45], both of the SSC12 QTL regions (11 cM and 86-89 cM) share an epistatic interaction; therefore, the ITGB3 and VTN genes would be powerful candidates for interactions between both proteins, as they have been reported previously in many different processes and species during pregnancy [46][47][48][49]. In the present work, we have also identified interactions between many of the 72 unique DE genes, showing the complex network of interacting genes that regulates litter size.…”

Section: Discussionmentioning

confidence: 69%

Differential Gene Expression in Ovaries of Pregnant Pigs with High and Low Prolificacy Levels and Identification of Candidate Genes for Litter Size

Fernández‐Rodríguez¹,

Muñoz²,

Fernández³

et al. 2010

Biology of Reproduction

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Previous results from a genome scan in an F(2) Iberian × Meishan pig intercross showed several chromosome regions associated with litter size traits in this species. In order to identify candidate genes underlying these quantitative trait loci (QTL), we performed an ovary gene expression analysis during the sow's pregnancy. F(2) sows were ranked by their estimated breeding values for prolificacy: six sows with the highest estimated breeding value (EBV) (i.e., high prolificacy) and six sows with the lowest EBV (low prolificacy) were selected. Samples were hybridized using an Affymetrix GeneChip porcine genome array. Statistical analysis with a mixed model approach identified 221 differentially expressed probes, representing 189 genes. These genes were functionally annotated in order to identify genetic pathways overrepresented in this list. Among the functional groups most represented was, in first position, immune system response activation against external stimulus. The second group consisted of integrated genes that regulate maternal homeostasis by complement and coagulation cascades. A third group was involved in lipid and fatty acid enzymes of metabolic processes, which participate in the steroidogenesis pathway. In order to identify powerful candidate genes for prolificacy, the second approach of this study was to merge microarray data with the QTL positional information affecting litter size, previously detected in the same experimental cross. As a result, we have identified 27 differentially expressed genes colocalizing with QTL for litter size traits, which fulfill the biological, positional, and functional criteria.

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Section: Discussionmentioning

confidence: 69%

Differential Gene Expression in Ovaries of Pregnant Pigs with High and Low Prolificacy Levels and Identification of Candidate Genes for Litter Size

Fernández‐Rodríguez¹,

Muñoz²,

Fernández³

et al. 2010

Biology of Reproduction

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“…Accumulating evidence suggests that integrin avb3 is a biomarker of uterine receptivity (6)(7)(8)(9)(10). Although integrin subunits of a6, b1, and b4 have been found in RL95-2 cells, and b3 is also claimed to present in RL95-2 cells…”

Section: Discussionmentioning

confidence: 99%

“…Integrin avb3 is increased in the luminal epithelium during the window of implantation in the mouse, rat, and human (6)(7)(8). An aberrant integrin avb3 expression pattern has been associated with unexplained infertility in humans (9,10).…”

mentioning

confidence: 99%

Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity

Zhang

Wei

Wang

et al. 2011

Fertility and Sterility

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“…This integrin is present in normal fertile patients but is missing in a subset of women with unexplained infertility and endometriosis (Lessey et al, 1994b). Indeed, aberrant endometrial expression of the integrin subtype a-5,b-3 occurs with high frequency in patients with prior IVF failure despite good embryo quality (Surrey et al, 2007). In the endometrium, osteopontin binds to integrin a-5,b-3 (vitronectin) and a-4,b-1, giving rise to speculation that it may mediate trophoblast-endometrial interactions during implantation.…”

Section: Impaired Implantationmentioning

confidence: 99%

Adenomyosis and infertility

Campo

Benagiano

2012

Reproductive BioMedicine Online

138

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The incidence of aberrant endometrial αvβ3 vitronectin expression in a high risk infertility population: could prolonged GnRH agonist therapy play a role?

Cited by 39 publications

References 18 publications

Differential Gene Expression in Ovaries of Pregnant Pigs with High and Low Prolificacy Levels and Identification of Candidate Genes for Litter Size

Differential Gene Expression in Ovaries of Pregnant Pigs with High and Low Prolificacy Levels and Identification of Candidate Genes for Litter Size

Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity

Adenomyosis and infertility

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