The incidence of postoperative thromboembolic complications following surgical resection of intracranial meningioma. A retrospective study of a large single center patient cohort

Hoefnagel, Daphna; Kwee, Lucy; Putten, Erik H.P. van; Kros, Johan M.; Dirven, Clemens M.F.; Dammers, Rúben

doi:10.1016/j.clineuro.2014.06.001

Cited by 74 publications

(54 citation statements)

References 39 publications

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“…Our study has similar findings with the literature including female predominance and age distribution (although we excluded the pediatric group) (4,8,17,18,23,35,37,42,46,49). In series of Wang et al (46), there was a higher female: male ratio in WHO grade 2 and 3 meningiomas, but we found no difference in our series.…”

Section: █ Discussionsupporting

confidence: 81%

“…Variables including patient characteristics, tumor localization, grade, surgical approach, intraoperative challenges and especially the follow-up period determine outcome. In the literature, there is a female predominance in adulthood meningiomas and a variable ratio of WHO grade II meningiomas (4,8,17,18,23,29,33,46). There is a known relatively high risk of postoperative venous thromboembolism (VTE) (1,6,9,12,20,21,26,28,34).…”

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confidence: 99%

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Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

Çeltikçi

Kaymaz²,

Akgül³

et al. 2016

Turkish Neurosurgery

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AIm: Meningioma literature has many large surgical case series, which have been references of text books and neurosurgical practice. Many of those series were published when stereotactic radiosurgery (SRS) was not so common or these series were in terms of World Health Organization (WHO) 2000 classification. In this study, we aimed to make an update to the current literature using WHO 2007 classification system. mATERIAl and mEThODS: Four hundred eighty-eight intracranial meningioma patients underwent open surgery in 2007-2013 and 449 of them were included in this study. All pathological specimens were re-evaluated in terms of WHO 2007 classification. All demographical and follow-up records and imaging archives were investigated by using our center's central automation system and National Central Population Management System. If records were not available or not adequate, investigators made phone calls to patients. Pediatric patients were excluded. RESulTS:Three hundred twenty-six female (76.2%) and 123 male (27.4%) patients were analyzed. Their ages ranged from 18 to 84 years (mean=51.6±11.9 years). The most common subtype of meningioma was meningothelial meningioma (51.7%), followed by atypical meningioma (20.3%). WHO Grade I meningiomas had statistically random localization distribution, but WHO Grade II meningiomas were more common in the convexity, parasagittal and middle fossa. Younger age was found to be significantly related with tumor recurrence or progression. Seventy-three (16.2%) patients underwent SRS and 64 (14.2%) patients underwent adjuvant radiotherapy (ART) after surgery. Convexity localization was found to be associated with recurrence, mortality and higher WHO 2007 grade.CONCluSION: Convexity meningiomas are associated with recurrence, mortality and higher WHO 2007 grade. Convexity meningiomas should be totally resected in order to achieve maximum benefit from surgery,

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Section: █ Discussionsupporting

confidence: 81%

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confidence: 99%

Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

Çeltikçi

Kaymaz²,

Akgül³

et al. 2016

Turkish Neurosurgery

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“…The histopathological finding varies with the grades. [ Table 2] [22] The NF2 gene that resides in this region on chromosome 22q is a tumour suppressor gene involved in sporadic and NF2-associated meningioma tumourigenesis . Mutations in NF2 gene is associated with sporadic meningioma, fibrous meningioma, transitional meningioma, meningothelial meningioma, atypical and anaplastic meningiomas .…”

Section: Resultsmentioning

confidence: 99%

“…[19][20][21][22][23][24][25][26] One patient experienced VTE and died because of pulmonary embolism. Meningothelial andtransitional meningiomas were the most common pathological subtypes of meningiomas.…”

Section: Discussionmentioning

confidence: 99%

A Radiology - Pathological Correlation Of Intracranial Meningioma in a Tertiary Care Hospital-A Retrospective Study

Kannan¹,

Krishnaveni²,

Anandan³

2017

Ann. Int. Med. Den. Res.

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Background:The study was conducted to understand the clinical algorithm of intracranial meningioma. Correlation was done by clinical presentation with radiological features and histopathology .The stress upon to understand the necessity for a team-approach between Clinician, Radiologist and Pathologist and vice versa is emphasised. Aim: To correlate histopathology of intracranial brain tumours with the Radiological features. Methods: This is a retrospective study ofintracranial brain tumours, diagnosed by histopathology as various types of meningioma. All the relevant clinical data of the patients were searched from the ward records. The various Radiological features were collected. Results: The total number of intracranial brain tumours studied at during the 5 years period was 51 cases among which 25 cases were diagnosed by histopathology as various types of meningioma conclusively . Spectroscopy provides molecular information with regard to meningiomas and potentially aid in biopsy planning. Surgical resections were done as follows: 17 cases resected as Simpson Grade 1, 3 cases resected as Simpson Grade 2, and 2 cases resected as Simpson grade 3. Venous thromboembolism was seen in 1 patient . Seven patients underwent Stereotactic radiosurgery, among which four patients attended SRS after surgery. Conclusion: The Simpsongrading of resection of meningioma correlated the degree of surgical resection completeness with symptomatic recurrence. Stereotactic radiosurgery is a safe and effective treatment for benign intracranial meningiomas with or without surgical resection. Intracranial meningioma needs correlation between Radiologist, Pathologist and Clinician.

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“…Studies have shown that other risk factors for VTE include age, sex, ethnicity, blood type, length of hospital stay, operative duration, and coagulation status [3,6,[8][9][10]14,[25][26][27][28][29][30][31][32][33][34][35][36][37][38]. Standard prophylactic measures for VTE include chemical anticoagulation, mechanical prophylaxis, and increased ambulation during the post-operative period [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. This paper seeks to review the relevant and current literature on VTE in brain tumor patients, with particular focus on the risk factors and presenting symptoms of VTE, treatment options for those with VTE, and a review of current prophylactic measures for VTE.…”

Section: Introductionmentioning

confidence: 99%

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Coté¹,

Smith

2015

J Hematol Thrombo Dis

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Venous thromboembolism (VTE) is a relatively common and well-described condition, affecting approximately 1-2% of the general population. VTE can lead to significant morbidity and death via pulmonary embolism (PE). During the post-operative period, VTE occurs at higher rates due to natural thrombotic responses to injury and limited post-operative mobility. In general, rates of post-operative VTE are higher in patients undergoing operations for cranial and spinal lesions than for lesions of other types, a phenomenon that is not fully explained. Several studies have demonstrated that other risk factors for VTE include age, sex, ethnicity, hospital stay length, and coagulation state. Aggressive chemical and mechanical measures for VTE prophylaxis are indicated in the postoperative period to prevent the formation of VTE. Here we review the literature on VTE in brain tumor patients, with a focus on their etiology, diagnosis, treatment, and prophylaxis.

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The incidence of postoperative thromboembolic complications following surgical resection of intracranial meningioma. A retrospective study of a large single center patient cohort

Cited by 74 publications

References 39 publications

Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

Retrospective analysis of 449 intracranial meningioma patients operated between years 2007 – 2013 in a single institute

A Radiology - Pathological Correlation Of Intracranial Meningioma in a Tertiary Care Hospital-A Retrospective Study

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

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