The increased hemoglobin oxygen affinity in COVID-19

Vogel, Dominik J; Formenti, Federico; Camporota, Luigi

doi:10.1152/ajplung.00280.2021

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Moreover, median methemoglobin was 1.5% [1.2–1.8] in patients with COVID-19 having received hydroxychloroquine versus 1.1% [1–1.3] in the absence of hydroxychloroquine ( P < 0.0001), with a maximal value of 2.5% in a critically ill 67-yr-old man. These results are in line with those recently communicated by Vogel et al ( 5 ). However, when considering the previously reported left shift of the ODC curve ( 6 ), it may be hypothesized that it could have been overestimated by overrepresented samples from a few patients in the analyses (i.e., 3,518 samples from only 43 patients), compared with an unmatched historical cohort, or the presence of samples with a too high P o 2 to accurately extrapolate P 50 ( 7 ).…”

supporting

confidence: 94%

Is there a shift of the oxygen-hemoglobin dissociation curve in COVID-19?

Gille

Sesé

Aubourg

et al. 2022

American Journal of Physiology-Lung Cellular and Molecular Phys

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supporting

confidence: 94%

Is there a shift of the oxygen-hemoglobin dissociation curve in COVID-19?

Gille

Sesé

Aubourg

et al. 2022

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…The findings of Gille et al ( 4 ) together with those of Vogel et al ( 9 ) communicated in their letter to the editor indeed exclude MetHb as main factor for a left shift of the in vivo oxygen dissociation curve in COVID-19. We previously already suggested a possible influence of varying nitric oxide (NO)-binding to Hb as an alternative explanation for this finding ( 10 ).…”

Section: Methemoglobinmentioning

confidence: 88%

Reply to Gille et al.

Böning

Bloch

Kuebler

2022

American Journal of Physiology-Lung Cellular and Molecular Phys

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TO THE EDITOR: We thank Dr. Gille and collaborators for their comment (1) to our review (2). The following statements in their letter have to be discussed: 1) In contrast to the findings of Vogel et al. ( 3), the in vivo oxygen dissociation curve is not left-shifted in the patients of their recent study (4). 2) There is no marked increase in methemoglobin concentration in their patients as suggested by us for Vogel's results. 3) Oxygen saturation is calculated as the sum of oxyhemoglobin (O 2 Hb) and carboxyhemoglobin (COHb).

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“…Three large studies using P 50 calculation from arterial samples show a left shift of the ODC (30, 33,46,56). In two the outcome is positively correlated to a low half saturation pressure (46,56), in one P 50 was higher in anemic subjects with a bad prognosis (56).…”

Section: P 50 Calculation From Single Arterial Samplesmentioning

confidence: 96%

The oxygen dissociation curve of blood in COVID-19–An update

et al. 2023

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An impressive effect of the infection with SARS-Co-19 is the impairment of oxygen uptake due to lung injury. The reduced oxygen diffusion may potentially be counteracted by an increase in oxygen affinity of hemoglobin. However, hypoxia and anemia associated with COVID-19 usually decrease oxygen affinity due to a rise in [2,3-bisphosphoglycerate]. As such, COVID-19 related changes in the oxygen dissociation curve may be critical for oxygen uptake and supply, but are hard to predict. A Pubmed search lists 14 publications on oxygen affinity in COVID-19. While some investigations show no changes, three large studies found an increased affinity that was related to a good prognosis. Exact causes remain unknown. The cause of the associated anemia in COVID-19 is under discussion. Erythrocytes with structural alterations of membrane and cytoskeleton have been observed, and virus binding to Band 3 and also to ACE2 receptors in erythroblasts has been proposed. COVID-19 presentation is moderate in many subjects suffering from sickle cell disease. A possible explanation is that COVID-19 counteracts the unfavorable large right shift of the oxygen dissociation curve in these patients. Under discussion for therapy are mainly affinity-increasing drugs.

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The increased hemoglobin oxygen affinity in COVID-19

Cited by 5 publications

References 6 publications

Is there a shift of the oxygen-hemoglobin dissociation curve in COVID-19?

Is there a shift of the oxygen-hemoglobin dissociation curve in COVID-19?

Reply to Gille et al.

The oxygen dissociation curve of blood in COVID-19–An update

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