The incremental prognostic value of sIL-2R and HGF in acute ischemic stroke

Abstract

Background: Inflammation affect long-term neurological outcome after acute ischemic stroke (AIS). Comprehensive and insightful understanding of correlation of inflammatory mediators and stroke outcome may offer new biomarkers or therapeutic approaches for AIS. Methods: We collected plasma from 204 AIS patients and 76 healthy controls, and ten cytokines (HGF, IL-1β, IL-2, sIL-2R, IL-5, IL-10, IL-16, MIP-3α, CD40L and MMP1) screened out by Immune Monitoring 65-Plex Human ProcartaPlex Panel were measured. Functional outcome 3 months after stroke was assessed using the modified Rankin Scale. To assess the prognostic ability of inflammatory mediators, we applied multivariate logistic regression and construction of multimarker score. Results: HGF, IL-10, IL-1β, MIP-3α, IL-2, sIL-2R, and IL-5 were significantly upregulated in AIS patients compared to controls. After multivariable adjustment, sIL-2R (OR, 1.138; 95% CI, 1.028-1.259; P=0.012) and HGF (OR, 1.121; 95% CI, 1.030-1.218; P=0.008) remained individually associated with unfavorable outcomes at 3 months after AIS (p < 0.05). Furthermore, adding sIL-2R and HGF to the conventional model significantly improved risk reclassification for unfavorable outcomes (continuous net reclassification improvement 32.18%, p < 0.001; integrated discrimination improvement 10.21%, p < 0.001). Conclusions: Higher plasma sIL-2R was a new independent predictor of unfavorable outcomes in AIS, and incorporation of sIL-2R and HGF into the conventional model significantly improved risk stratification for unfavorable outcomes.

Paradoxical role of hepatocyte growth factor in ischemic stroke: stroke risk/stroke recovery

“…They explained it by its pathological role in plaque progression and instability and greater degree of baseline endothelial dysfunction [20] with subsequent infarct expansion and hemorrhagic transformation [31]. This conclusion was supported by recent study by Zhao and colleagues; they found that soluble interleukin-2 receptors (sIL-2R) and HGF associated with unfavorable outcomes at 3 months after acute ischemic stroke [32].…”