The Induction of Ovulation With Clomiphene and Its Assessment by Biological Methods

Investigation of Amenorrhea with a Simplified Clomiphene Test

“…We think that our modification of the clomiphene test, with hormone determinations 5 and 12 days after treatment ends, is both reliable and convenient, and therefore clinically useful. The results of our study largely confirm those of previous studies (4,6,7). Patient responses to our simplified clomiphene test did not clearly reveal the etiology of hypothalamic amenorrhea because these responses varied from patient to patient even in the same diagnosis group.…”

“…Thus, positive response is diagnostic, but negative response is not. A possible ovarian failure can be identified from high FSH and LH values which are, of course, confirmed by an unresponsiveness to clomiphene (7).…”

An Appraisal of Clomiphene in the Induction of Ovulation

“…An abnormal luteal phase in clomipheneinduced ovulation has been noted by many authors (Jones and de Moraes-Ruehsen, 1967;Osmond-Clarke et al, 1968;Van Hall and Mastboom, 1969;Jones et al, 1970;Murthy et al, 1971). Murray and Osmond-Clarke (1971) stated that approximately 30% of patients who ovulated had a short luteal phase that recurred after each course.…”

Scientific and Clinical Aspects of Fertilization and Implantation

“…The upper one-third of the vaginal epithelium shows characteristic responses to endogenous and exogenous cestrogenic, androgenic and progestogenic hormones. The patient can be taught to take serial aspirations from the posterior fornix, and vaginal cytology is therefore particularly useful in the treatment of infertility because it provides instant information (Osmond-Clarke et al 1968). However, the smears cannot be assessed by counting either a maturation or a karyopyknotic index.…”