The Inflammatory Response in Tissue Repair

Frangogiannis, Nikolaos G.

doi:10.1002/9783527692156.ch60

Cited by 11 publications

(7 citation statements)

References 127 publications

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“…[22] The secretome's role in modulating regenerative processes may rely on initial inflammatory activity created by the early release of pro-inflammatory cytokines, such as IL-1𝛼, IL-1𝛽 or IL-2 (Figure 3D), which are required to activate elements of innate response and may be involved in the proliferation and differentiation of reparative cells. [67,68] On the other hand, the timedependent release of anti-inflammatory cytokines, IL-10, and proregenerative molecules such as BDNF, NGF, or even TGF-𝛽 (Fig- ure 3E) helps to restrict the immune response while also triggering axonal sprouting and regeneration. [69] Given the generally low neuroregenerative capacity observed in SCI, it is of the utmost importance to develop therapies that can promote better regeneration.…”

Section: Hascs Secretome Released From Starpeg-hep Hydrogels Promotes...mentioning

confidence: 99%

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Silva

Schirmer

Pinho

et al. 2023

Adv Healthcare Materials

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Adipose tissue‐derived stem cells (ASCs) have been shown to assist regenerative processes after spinal cord injury (SCI) through their secretome, which promotes several regenerative mechanisms, such as inducing axonal growth, reducing inflammation, promoting cell survival, and vascular remodeling, thus ultimately leading to functional recovery. However, while systemic delivery (e.g., i.v. [intravenous]) may cause off‐target effects in different organs, the local administration has low efficiency due to fast clearance by body fluids. Herein, a delivery system for human ASCs secretome based on a hydrogel formed of star‐shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan heparin (Hep) that is suitable to continuously release pro‐regenerative signaling mediators such as interleukin (IL)‐4, IL‐6, brain‐derived neurotrophic factor, glial‐cell neurotrophic factor, and beta‐nerve growth factor over 10 days, is reported. The released secretome is shown to induce differentiation of human neural progenitor cells and neurite outgrowth in organotypic spinal cord slices. In a complete transection SCI rat model, the secretome‐loaded hydrogel significantly improves motor function by reducing the percentage of ameboid microglia and systemically elevates levels of anti‐inflammatory cytokines. Delivery of ASC‐derived secretome from starPEG‐Hep hydrogels may therefore offer unprecedented options for regenerative therapy of SCI.

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Section: Hascs Secretome Released From Starpeg-hep Hydrogels Promotes...mentioning

confidence: 99%

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Silva

Schirmer

Pinho

et al. 2023

Adv Healthcare Materials

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show abstract

“…Inflammation plays a crucial role in both chronic and degenerative diseases, but it also facilitates regeneration in injured tissues by clearing damaged cells and promoting tissue regrowth [ 152 , 153 ]. Insufficient inflammation can lead to damage of tissues by harmful stimuli, while persistent unresolved inflammation can result in various pathologies, such as fibrosis [ 154 ] and cancer [ 155 ].…”

Section: Is Irisin An Oracle To Tissue Repair/regeneration?mentioning

confidence: 99%

Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration

Zhang

Wang

Kang

et al. 2023

IJMS

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Physical activity is well-established as an important protective factor against degenerative conditions and a promoter of tissue growth and renewal. The discovery of Fibronectin domain-containing protein 5 (FNDC5) as the precursor of Irisin in 2012 sparked significant interest in its potential as a diagnostic biomarker and a therapeutic agent for various diseases. Clinical studies have examined the correlation between plasma Irisin levels and pathological conditions using a range of assays, but the lack of reliable measurements for endogenous Irisin has led to uncertainty about its prognostic/diagnostic potential as an exercise surrogate. Animal and tissue-engineering models have shown the protective effects of Irisin treatment in reversing functional impairment and potentially permanent damage, but dosage ambiguities remain unresolved. This review provides a comprehensive examination of the clinical and basic studies of Irisin in the context of degenerative conditions and explores its potential as a therapeutic approach in the physiological processes involved in tissue repair/regeneration.

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“…Inflammation plays a crucial role in both chronic and degenerative diseases, but it also facilitates regeneration in injured tissues by clearing damaged cells and promoting tissue regrowth [95,96]. Insufficient inflammation can lead to damage of tissues by harmful stimuli, while persistent unresolved inflammation can result in various pathologies, such as fibrosis [97] and cancer [98].…”

Section: Role Of Irisin In Regulating Inflammatory Responsesmentioning

confidence: 99%

Unlocking the Therapeutic Potential of Irisin: Harnessing its Function in Degenerative Disorders and Tissue Regeneration

Zhang¹,

Wang²,

Hj³

et al. 2023

Preprint

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Physical activity is well-established as an important protective factor against degenerative conditions and a promoter of tissue growth and renewal. The discovery of FNDC5 as the precursor of irisin in 2012 sparked significant interest in its potential as a diagnostic biomarker and a therapeutic agent for various diseases. Clinical studies have examined the correlation between plasma irisin levels and pathological conditions using a range of assays, but the lack of reliable measurements for endogenous irisin has led to uncertainty about its prognostic/diagnostic potential as an exercise surrogate. Animal and tissue-engineering models have shown the protective effects of irisin treatment in reversing functional impairment and potentially permanent damage, but dosage ambiguities remain unresolved. This review provides a comprehensive examination of the clinical and basic studies of irisin in the context of degenerative conditions and explores its potential as a therapeutic approach in the physiological processes involved in tissue repair/regeneration.

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The Inflammatory Response in Tissue Repair

Cited by 11 publications

References 127 publications

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration

Unlocking the Therapeutic Potential of Irisin: Harnessing its Function in Degenerative Disorders and Tissue Regeneration

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