The Influence of 5-Hydroxytryptamine (Serotonin) on Blood Flow in the Dog Pulp

Kim, Sungpyo; Trowbridge, Henry O.; Dörscher-Kim, J.

doi:10.1177/00220345860650051001

Cited by 22 publications

(8 citation statements)

References 19 publications

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“…It is estimated to be 40-50ml/min/100g of pulp tissue in a mature tooth as determined by radioactive microsphere techniques. [44][45][46] This flow is relatively high, compared to that of other oral tissues and skeletal muscle. 47 Numerous shunt vessels have also been observed in the dental pulp, although their function is less well understood.…”

Section: Pulp Microcirculationmentioning

confidence: 99%

An overview of the dental pulp: its functions and responses to injury

Yu¹,

Abbott²

2007

Australian Dental Journal

238

158

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The dental pulp is a unique tissue and its importance in the long-term prognosis of the tooth is often ignored by clinicians. It is unique in that it resides in a rigid chamber which provides strong mechanical support and protection from the microbial rich oral environment. If this rigid shell loses its structural integrity, the pulp is under the threat of the adverse stimuli from the mouth, such as caries, cracks, fractures and open restoration margins, all of which provide pathways for micro-organisms and their toxins to enter the pulp. The pulp initially responds to irritation by becoming inflamed and, if left untreated, this will progress to pulp necrosis and infection. The inflammation will also spread to the surrounding alveolar bone and cause periapical pathosis. The magnitude of pulp-related problems should not be underestimated since their most serious consequence is oral sepsis, which can be life threatening, and hence correct diagnosis and management are essential. Clinicians must have a thorough understanding of the physiological and pathological features of the dental pulp as well as the biological consequences of treatment interventions.

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Section: Pulp Microcirculationmentioning

confidence: 99%

An overview of the dental pulp: its functions and responses to injury

Yu¹,

Abbott²

2007

Australian Dental Journal

238

158

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“…The mean values of PBF measurements in this study ranged from 0.148 to 0.182 ml/min/ g, while measurement with RMSs in canine teeth yielded PBF values of about 28 ml/min/ 100 g and 41 ml/min/100 g 15,18) . When these differences between the CMS method and the RMS method are taken into consideration, the PBF values of this study, being comparable to those (about 22 ml/min/100 g) measured by the RMS method 16) , appear reasonable.…”

Section: Discussionmentioning

confidence: 49%

“…6 RMSs/10 kg body weight 15,18) . In contrast, RMBF measurement in dogs weighing about 20 kg required ‫01ן11-3‬ 6 CMSs 6,7,12) .…”

Section: Discussionmentioning

confidence: 99%

“…Pulpal blood flow (PBF) has been measured using such means as radioactively labeled microspheres (RMSs) 15,16,18) , fluorescent microspheres (FMSs) 20,29) , H 2 gas distribution techniques 28) , laser Doppler flowmetry (LDF) 25) , and the xenon washout method 17) . LDF is non-invasive, provides continuous data, and can be applied in human subjects; thus, it is the most common technique in current use 1,24) .…”

Section: Introductionmentioning

confidence: 99%

“…The FMS method has already been adopted for the determination of rat PBF 20,29) . Values for PBF measured by the RMS method are expressed with the unit (ml/min/100 g) based on wet weight 13,15,16,18) , while PBF semi-quantified and visualized by the FMS method are calculated with the unit (ml/min/cm 3 or ml/min/ mm 3 ) based on volume 20,29) . The FMS method is appropriate only in small animals 10) ; however, PBF values have been measured by the RMS method only in dogs.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Pulpal Blood Flow in Dogs with Nonradioactive Colored Microspheres.

Tanaka

Kaneko

2001

Bull. Tokyo Dent. Coll.

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The viability of dental pulp depends largely on regional blood flow, as in other organs. Measurement of absolute pulpal blood flow (PBF) and comparisons with blood flow in other organs allow the prediction of microvascular regulation in dental pulp. In previous studies, PBF was measured in dogs mainly with radioactive microspheres. However, this established technique is inaccessible to many investigators due to concerns over radiation safety and radioactive waste. To overcome these limitations, a new method has been introduced that involves the use of nonradioactive colored microspheres for measuring regional blood flow in the myocardium and in other organs in animals. However, no previous studies have investigated the use of this method to measure PBF in dogs. We attempted to determine whether blood flow in dental pulp, which comprises a small amount of the total tissue in dogs, could be measured using this technique by comparing the measured values with those for regional myocardial blood flow. Mean blood flow values were between 0.148 and 0.182ml/min/g for dental pulp at four different sites and about 1.0 ml/min/g in regional myocardium. These values are comparable to those previously reported using radioactive microspheres. As nonradioactive colored microspheres safely permitted measurement of absolute PBF in dogs, this technique appears to be useful for research into microvascular blood flow in dental pulp.

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Haemodynamic regulation of the dental pulp

Kim¹,

Dörscher-Kim²

1990

Dynamic Aspects of Dental Pulp

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The Influence of 5-Hydroxytryptamine (Serotonin) on Blood Flow in the Dog Pulp

Cited by 22 publications

References 19 publications

An overview of the dental pulp: its functions and responses to injury

An overview of the dental pulp: its functions and responses to injury

Measurement of Pulpal Blood Flow in Dogs with Nonradioactive Colored Microspheres.

Haemodynamic regulation of the dental pulp

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