The influence of carrier type, physical characteristics, and blending techniques on the performance of dry powder inhalers

Mahar, Riya; Chakraborty, Arpita; Nainwal, Nidhi

doi:10.1016/j.jddst.2022.103759

Cited by 10 publications

(3 citation statements)

References 135 publications

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“…There is a great need for innovative solutions that boost the stability of biological drugs and vaccines and enhance the solubility and dissolution characteristics. Additionally, advanced techniques convert the liquid formulation to a solid powder and reduce the load on the cold chain of transportation and handling [16]. Moreover, TFF typically yields high-potency powders with few inactive components, which is advantageous for medication administration.…”

Section: Characteristics Of Nanoparticles Produced By Tffmentioning

confidence: 99%

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

Pardeshi¹,

Kole

Kapare

et al. 2022

Pharmaceutics

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The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia.

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Section: Characteristics Of Nanoparticles Produced By Tffmentioning

confidence: 99%

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

Pardeshi¹,

Kole

Kapare

et al. 2022

Pharmaceutics

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“…They can involve a single phase, with the goal of achieving temperature homogenization in the product, or multiple phases, aiming to disperse and uniform the concentration of various ingredients. Thus, this operation can be found in the production of food and beverages [1], in the production of polymers [2], in the preparation of paints [3], in chemical and petrochemical processes [4] and in the preparation of pharmaceuticals [5], among others. Process parameters, such as process time, energy consumption or the quality of the final product can be directly related to a correct mixing process [6].…”

Section: Introductionmentioning

confidence: 99%

A Novel Experimental Apparatus for Characterizing Flow Regime in Mechanically Stirred Tanks through Force Sensors

Magos-Rivera,

Avilés-Cruz,

Ramírez-Muñoz

2024

Sensors

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Pressure fluctuations in a mixing tank can provide valuable information about the existing flow regime within the tank, which in turn influences the degree of mixing that can be achieved. In the present work, we propose a prototype for identifying the flow regime in mechanically stirred tanks equipped with four vertical baffles through the characterization of pressure fluctuations. Our innovative proposal is based on force sensors strategically placed in the baffles of the mixing tank. The signals coming from the sensors are transmitted to an electronic module based on an Arduino UNO development board. In the electronic module, the pressure signals are conditioned, amplified and sent via Bluetooth to a computer. In the computer, the signals can be plotted or stored in an Excel file. In addition, the proposed system includes a moving average filtering and a hierarchical bottom-up clustering analysis that can determine the real-time flow regime (i.e., the Reynolds number, Re) in which the tank was operated during the mixing process. Finally, to demonstrate the versatility of the proposed prototype, experiments were conducted to identify the Reynolds number for different flow regimes (static, laminar, transition and turbulent), i.e., 0≤Re≤ 42,955. Obtained results were in agreement with the prevailing consensus on the onset and developed from different flow regimes in mechanically stirred tanks.

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“…Carriers play a crucial role in dry powder inhalers (DPIs) for pulmonary drug delivery, they ensure uniform drug dispersion, facilitate smooth flow for effective aerosolization, aid lung targeting, maintain stability, and enhance patient compliance, all pivotal for precise, reliable, and targeted pulmonary drug delivery and improved respiratory treatment outcomes. Therefore, the selection of an appropriate carrier system is essential for the effectiveness of DPIs [1]. This research aimed to develop novel carrier systems consisting of one saccharide (Raffinose, Trehalose) and two amino acids (L-Leucine, L-Arginine, Glycine).…”

mentioning

confidence: 99%

Development of novel dry powder carrier systems for pulmonary drug delivery

Soliman,

Ambrus

2024

VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science

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The influence of carrier type, physical characteristics, and blending techniques on the performance of dry powder inhalers

Cited by 10 publications

References 135 publications

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

A Novel Experimental Apparatus for Characterizing Flow Regime in Mechanically Stirred Tanks through Force Sensors

Development of novel dry powder carrier systems for pulmonary drug delivery

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