The Influence of Gestational Age and Size on the Absorption of D‐Xylose and D‐Glucose from the Small Intestine of the Human Neonate

McNeish, A S; Ducker, D A; Warren, I. F.; Davies, David; Harran, M. J.; Hughes, Christopher A.

doi:10.1002/9780470720530.ch15

Cited by 9 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, sodium glucose-linked transporter 1 (SGLT1) gene expression is greater in term than in either preterm feeding-naive or fed pigs (54). In human infants, glucose absorption capacity cor-relates positively with GAB; infants born prematurely demonstrate lower V max of D-glucose absorption compared with those born at term (45,60), and absorption of leucine is reduced by 47% in preterm versus term pigs (54). In addition to the effects of gastric emptying and nutrient absorptive capacities, the effect of first-pass metabolism on plasma nutrient levels must also be considered.…”

Section: Discussionmentioning

confidence: 99%

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets

Naberhuis

Suryawan

Nguyen

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Postnatal growth of lean mass is commonly blunted in preterm infants and may contribute to short- and long-term morbidities. To determine whether preterm birth alters the protein anabolic response to feeding, piglets were delivered at term or preterm, and fractional protein synthesis rates (Ks) were measured at 3 days of age while fasted or after an enteral meal. Activation of signaling pathways that regulate protein synthesis and degradation were determined. Relative body weight gain was lower in preterm than in term. Gestational age at birth (GAB) did not alter fasting plasma glucose or insulin, but when fed, plasma insulin and glucose rose more slowly, and reached peak value later, in preterm than in term. Feeding increased Ks in longissimus dorsi (LD) and gastrocnemius muscles, heart, pancreas, and kidney in both GAB groups, but the response was blunted in preterm. In diaphragm, lung, jejunum, and brain, feeding increased Ks regardless of GAB. Liver Ks was greater in preterm than term and increased with feeding regardless of GAB. In all tissues, changes in 4EBP1, S6K1, and PKB phosphorylation paralleled changes in Ks. In LD, eIF4E·eIF4G complex formation, phosphorylation of TSC2, mTOR, and rpS6, and association of mammalian target of rapamycin (mTOR1) complex with RagA, RagC, and Rheb were increased by feeding and blunted by prematurity. There were no differences among groups in LD protein degradation markers. Our results demonstrate that preterm birth reduces weight gain and the protein synthetic response to feeding in muscle, pancreas, and kidney, and this is associated with blunted insulin- and/or amino acid-induced translation initiation signaling.

show abstract

Section: Discussionmentioning

confidence: 99%

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets

Naberhuis

Suryawan

Nguyen

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…The details of the technique have been described elsewhere (15,16). Briefly solutions containing 0-40mM glucose, 134mM NaCl, and made iso osmolar with mannitol, were perfused at standard rate into the distal duodenum of groups of neonates of different age and gestational age.…”

Section: Studies In Humansmentioning

confidence: 99%

Development of D‐Glucose Absorption in the Perinatal Period

McNeish,

Mayne,

Ducker

et al. 1983

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

“…In animals, a dramatic growth spurt occurs in the gut during the neonatal period, and associated with this are changes in gut structure and function (4). In both animals and humans, neonatal changes occur in gut mot ility (5), ac id and enzyme secretion (4), and in gut absorptive capacity (6). Changes also occur in the endocrine re sponse to the absorption of nutrients , with a progressively greater insulin response to oral glucose during the first po stnatal days (7,8) .…”

mentioning

confidence: 99%

Hormones and Postnatal Adaptation to Enteral Nutrition

Aynsley‐Green

1983

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

The Influence of Gestational Age and Size on the Absorption of D‐Xylose and D‐Glucose from the Small Intestine of the Human Neonate

Cited by 9 publications

References 30 publications

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets

Development of D‐Glucose Absorption in the Perinatal Period

Hormones and Postnatal Adaptation to Enteral Nutrition

Contact Info

Product

Resources

About