The influence of hepatic function on prostate cancer outcomes after radical prostatectomy

Bañez, Lionel L.; Loftis, Richard M.; Freedland, Stephen J.; Presti, Joseph C.; Aronson, William J.; Amling, Christopher L.; Kane, Christopher J.; Terris, Martha K.

doi:10.1038/pcan.2010.3

Cited by 25 publications

(21 citation statements)

References 24 publications

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“…10 This database includes information on patient age at surgery, race, height, weight, clinical stage, grade of cancer on diagnostic biopsies, preoperative PSA, surgical specimen pathology (specimen weight, tumor grade, stage, and surgical margin status), and follow-up PSA data. Body mass index was calculated as weight in kilograms divided by height in meters squared (kg/m 2 ).…”

Section: Methodsmentioning

confidence: 99%

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Do Nomograms Designed to Predict Biochemical Recurrence (BCR) Do a Better Job of Predicting More Clinically Relevant Prostate Cancer Outcomes than BCR? A Report from the SEARCH Database Group

Teeter

Presti

Aronson

et al. 2013

Urology

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OBJECTIVE To examine the ability of various postoperative nomograms to predict prostate cancer-specific mortality (PCSM) and to validate that they could predict aggressive biochemical recurrence (BCR). Prostate-specific antigen (PSA), grade, and stage are the classic triad used to predict BCR after radical prostatectomy (RP). Multiple nomograms use these to predict risk of BCR. A previous study showed that several nomograms could predict aggressive BCR (prostate-specific antigen doubling time [PSADT] <9 months) more accurately than BCR. However, it remains unknown if they can predict more definitive endpoints, such as PCSM. METHODS We performed Cox analyses to examine the ability of 4 postoperative nomograms, the Duke Prostate Center (DPC) nomogram, the Kattan postoperative nomogram, the Johns Hopkins Hospital (JHH) nomogram, and the joint Center for Prostate Disease Research(CPDR)/Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) nomogram to predict BCR and PCSM among 1778 men in the Shared Equal Access Regional Cancer Hospital (SEARCH) database who underwent RP between 1990 and 2009. We also compared their ability to predict BCR and aggressive BCR in a subset of men. We calculated the c-index for each nomogram to determine its predictive accuracy for estimating actual outcomes. RESULTS We found that each nomogram could predict aggressive BCR and PCSM in a statistically significant manner and that they all predicted PCSM more accurately than they predicted BCR (ie, with higher c-index values). CONCLUSION Currently available nomograms used to predict BCR accurately predict PCSM and other more clinically relevant endpoints. Moreover, not only do they significantly predict PCSM, but do so with generally greater accuracy than BCR.

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Section: Methodsmentioning

confidence: 99%

“…Therefore, we examined the ability of various post-operative nomograms to predict PCSM and to redemonstrate their ability to predict aggressive BCR in the multicenter Shared Equal Access Regional Cancer Hospital (SEARCH) database, which includes clinicopathological information on men treated with RP at 4 Veterans Affairs medical centers. 10 …”

mentioning

confidence: 99%

Do Nomograms Designed to Predict Biochemical Recurrence (BCR) Do a Better Job of Predicting More Clinically Relevant Prostate Cancer Outcomes than BCR? A Report from the SEARCH Database Group

Teeter

Presti

Aronson

et al. 2013

Urology

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“…13 We determined the effect of preoperative weight change in the year before RP on adverse pathology and BCR using the SEARCH (Shared Equal Access Regional Cancer Hospital) database, which includes men treated with RP at multiple equal access centers. 14 …”

Section: Introductionmentioning

confidence: 99%

Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database

Whitley

Moreira

Thomas

et al. 2011

Prostate Cancer Prostatic Dis

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BACKGROUND:We examined the relationship between weight change in the year before radical prostatectomy (RP) and biochemical recurrence (BCR) and adverse pathology. METHODS:We abstracted data from 359 men undergoing RP in the SEARCH (Shared Equal Access Regional Cancer Hospital) database between [2001][2002][2003][2004][2005][2006][2007]. Logistic regression and Cox proportional hazards models were used to test the association between weight change in the year before surgery and adverse pathology and BCR, respectively. RESULTS:In all, 152 (42%) men gained weight, 193 (54%) lost weight and 14 (4%) had the same weight. Among weight gainers, median gain was 2.4 kg and among weight losers, median loss was 2.7 kg. As a continuous variable, weight change was not associated with adverse pathology or BCR (all P40.05). In secondary analysis, on multivariate analysis, men gaining X2.5 kg were at higher BCR risk (hazards ratio ¼ 1.65, 95% confidence interval (CI): 1.03-2.64, P ¼ 0.04) while weight loss X2.5 kg was not associated with BCR (hazards ratio ¼ 0.83, 95% CI: 0.54-1.29, P ¼ 0.41). CONCLUSIONS:As a continuous variable, weight change was not associated with outcome. In secondary hypothesisgenerating analyses, weight gain X2.5 kg in the year before surgery, regardless of final body mass index, was associated with increased BCR following RP. If validated, these data suggest weight gain X2.5 kg may promote prostate cancer progression.

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“…After obtaining Institutional Review Board approval from each institution, data from patients undergoing radical prostatectomy between 1991 and 2009 at 3 Veteran Affairs Medical Center (West Los Angeles and Palo Alto, CA and Durham, NC) were combined into the SEARCH database (5). The database includes information on patient age at surgery, race, height, weight, clinical stage, cancer grade on diagnostic biopsies, preoperative PSA, surgical specimen pathology (specimen weight, tumor grade, stage and surgical margin status) and follow-up PSA.…”

Section: Study Populationmentioning

confidence: 99%

High serum folate is associated with reduced biochemical recurrence after radical prostatectomy: Results from the SEARCH Database

et al. 2013

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Introduction:To analyze the association between serum levels of folate and risk of biochemical recurrence after radical prostatectomy among men from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Materials and Methods: Retrospective analysis of 135 subjects from the SEARCH database treated between 1991-2009 with available preoperative serum folate levels. Patients' characteristics at the time of the surgery were analyzed with ranksum and linear regression. Uni-and multivariable analyses of folate levels (log-transformed) and time to biochemical recurrence were performed with Cox proportional hazards. Results: The median preoperative folate level was 11.6ng/mL (reference = 1.5-20.0ng/mL). Folate levels were significantly lower among African-American men than Caucasians (P = 0.003). In univariable analysis, higher folate levels were associated with more recent year of surgery (P < 0.001) and lower preoperative PSA (P = 0.003). In univariable analysis, there was a trend towards lower risk of biochemical recurrence among men with high folate levels (HR = 0.61, 95%CI = 0.37-1.03, P = 0.064). After adjustments for patients characteristics' and pre-and post-operative clinical and pathological findings, higher serum levels of folate were independently associated with lower risk for biochemical recurrence (HR = 0.42, 95%CI = 0.20-0.89, P = 0.023). Conclusion: In a cohort of men undergoing radical prostatectomy at several VAs across the country, higher serum folate levels were associated with lower PSA and lower risk for biochemical failure. While the source of the folate in the serum in this study is unknown (i.e. diet vs. supplement), these findings, if confirmed, suggest a potential role of folic acid supplementation or increased consumption of folate rich foods to reduce the risk of recurrence.

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The influence of hepatic function on prostate cancer outcomes after radical prostatectomy

Cited by 25 publications

References 24 publications

Do Nomograms Designed to Predict Biochemical Recurrence (BCR) Do a Better Job of Predicting More Clinically Relevant Prostate Cancer Outcomes than BCR? A Report from the SEARCH Database Group

Do Nomograms Designed to Predict Biochemical Recurrence (BCR) Do a Better Job of Predicting More Clinically Relevant Prostate Cancer Outcomes than BCR? A Report from the SEARCH Database Group

Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database

High serum folate is associated with reduced biochemical recurrence after radical prostatectomy: Results from the SEARCH Database

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