The Influence of Hypotaurine on Taurine Transport in Isolated Renal Cortex Tubules

Gingery, Robben; Chesney, Russell W.

doi:10.3181/00379727-164-40817

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…1978] and for the uptake of taurine in rat brush border membrane [Rozen et al, 1979], In some experiments, we measured taurine uptake up to 4 mM taurine (data not shown) and we found no evidence for a sec ond taurine transport system with a low affinity although this has been reported in rat kidney cortex slices [Chesneyet al. 1976: Chesney andJax, 1977] and in isolated tu bules [Gingery and Chesney, 1980]. In order to compare the transport of tau rine into BBMV isolated from tau(-) and tau(+) mice, it was important to ensure that BBMV have the same characteristics in all strains.…”

Section: Discussionmentioning

confidence: 59%

Taurine Transport in Brush Border Membrane Vesicles Isolated from Hyper- and Normotaurinuric Mouse Kidney

Jean¹,

Poujeol²,

Ripoche³

1984

Kidney Blood Press Res

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The mouse strain C57BL is characterized by a high urinary fractional excretion of taurine. Hypertaurinuric [tau(-)] C57BL mice and three normal taurine ‘excretors’ [tau(+)] – Swiss, A/J, and C3H – were compared. Clearance experiments showed that fractional excretion of taurine was 4-8 times higher in C57BL relative to the other strains. Transport studies performed in brush border membrane vesicles, isolated from C57BL and C3H mouse renal cortex, showed that D-glucose uptake was similar in both strains while the taurine uptake appeared to be faster in tau(+) than in tau(-) mice. This difference was observed only in the presence of an inwardly directed NaCl gradient. The comparison of kinetic parameters showed a significant difference of apparent K_m values: 90.8 ± 11.4 µM in tau(+) mice vs. 129.5 ± 17.1 µM in tau(-) mice. J_max were not significantly different in both strains. These observations suggest a lower affinity of the taurine brush border membrane carrier in the hypertaurinuric strain as compared to the normotaurinuric mice. It is concluded that, in addition to a possible alteration of peritubular taurine efflux described by Rozen et al. (1983), a defect of taurine transport at the luminal membrane cannot be excluded and could account for the hypertaurinuria of the C57BL mice.

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Section: Discussionmentioning

confidence: 59%

Taurine Transport in Brush Border Membrane Vesicles Isolated from Hyper- and Normotaurinuric Mouse Kidney

Jean¹,

Poujeol²,

Ripoche³

1984

Kidney Blood Press Res

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Tubular Transport of Amino Acids and Small Peptides

Silbernagl

1992

Comprehensive Physiology

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The sections in this article are: The Intact Kidney Plasma Concentrations of Amino Acids Normal Excretion of Amino Acids Variability of Aminoaciduria Interorgan Transport and Renal Metabolism of Amino Acids The Tubule Level Sites of Reabsorption Internephron Heterogeneity Reabsorption Kinetics Transport Steps at the Membrane Level Brush Border Basolateral Membrane: Exit and Uptake Carrier, Pore, or Enzymatic Cycle? Secretion of Amino Acids Specificity of The Reabsorption Mechanisms Stereospecificity Specificities of the Different Reabsorption Systems Hyperaminoaciduria Renal Handling of Oligopeptides Prereabsorptive Hydrolysis in the Tubule Lumen Glutathione and Other γ‐Glutamyl Peptides Reabsorption of Intact Peptides

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Studies on the Renal Handling of Taurine: Changes during Maturation and After Altered Dietary Intake

Chesney

Friedman

Albright

et al. 1982

Advances in Experimental Medicine and Biology

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The Influence of Hypotaurine on Taurine Transport in Isolated Renal Cortex Tubules

Cited by 4 publications

References 4 publications

Taurine Transport in Brush Border Membrane Vesicles Isolated from Hyper- and Normotaurinuric Mouse Kidney

Taurine Transport in Brush Border Membrane Vesicles Isolated from Hyper- and Normotaurinuric Mouse Kidney

Tubular Transport of Amino Acids and Small Peptides

Studies on the Renal Handling of Taurine: Changes during Maturation and After Altered Dietary Intake

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