The influence of statins on the risk of post-stroke epilepsy

Vitturi, Bruno Kusznir; Gagliardi, Rubens José

doi:10.1007/s10072-020-04298-5

Cited by 23 publications

(22 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both the type and the dosage of statins are associated with the development of PSE, and not just the use of them. 44 However, the type and the dosage of statins were not included in our analysis, this was a potential limitation. In addition, there were still two limitations in this study.…”

Section: Discussionmentioning

confidence: 99%

Predictive Values of the SeLECT Score and IL-1β for Post-Stroke Epilepsy

Shen

Yang

Tang

2021

NDT

View full text Add to dashboard Cite

Purpose: To establish a new prognostic tool for the prediction of post-stroke epilepsy (PSE) through combining the SeLECT score with IL-1β. Patients and Methods: This prospective observational study included 915 patients with acute ischemic stroke. The SeLECT score was calculated, and serum IL-1β levels were measured within 24 h of their admission. One unprovoked late seizure following the acute phase of stroke was diagnosed as PSE. All patients were divided into PSE group and non-PSE group according to the occurrence of PSE. Multivariate analysis was performed to determine the independent associations between the SeLECT score, IL-1β and PSE. Receiver operating characteristic (ROC) curve was employed to assess the predictive values of the SeLECT score, IL-1β and their combination for PSE. Results: Fifty-three patients occurred PSE within 1 year after stroke onset (5.8%). Multivariate analysis demonstrated that the SeLECT score [odds ratio (OR): 1.416, 95% confidence interval (CI): 1.191-1.863, P=0.013] and IL-1β (OR: 1.457, 95% CI: 1.215-1.894, P<0.001) were independent risk factors for PSE after adjusting for more than one comorbidity, stroke laterality, large-artery atherosclerosis, thrombolysis, age and use of statins. The AUC of the SeLECT score and IL-1β for predicting PSE was 0.756 (SE: 0.033, 95% CI: 0.692-0.819) and 0.811 (SE: 0.032, 95% CI: 0.748-0.875), respectively. The AUC of their combination was 0.933 (SE: 0.027, 95% CI: 0.880-0.985). Z test showed that the AUC of their combination was significantly higher than that of the SeLECT score or IL-1β alone (0.933 vs 0.756, Z=4.151, P<0.01; 0.933 vs 0.811, Z=2.914, P<0.01). Combination prediction of the SeLECT score and IL-1β for PSE had a high predictive value with a sensitivity of 88.06% and specificity of 82.37%. Conclusion:The combination of the SeLECT score and IL-1β had a potential to act as a new prognostic tool for the prediction of PSE.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictive Values of the SeLECT Score and IL-1β for Post-Stroke Epilepsy

Shen

Yang

Tang

2021

NDT

View full text Add to dashboard Cite

show abstract

“…In patients with epilepsy, statin use, especially in the acute phase of ischemic stroke, may reduce the risk of post-stroke early-onset seizures [127]. Adequate statin treatment after ischemic stroke may lower the risk of PSE [128].…”

Section: Treatment Strategy: Adults In General and In Elderly 51 Prmentioning

confidence: 99%

Cerebrovascular Disease; A Leading Cause of Epilepsy

Obata¹,

Sato²,

Ohara³

et al. 2021

Epilepsy - Update on Classification, Etiologies, Instrumental Diagnosis and Treatment

View full text Add to dashboard Cite

Various types of cerebrovascular diseases can result in epilepsy in any age, especially in the elderly. Besides well-known cause of epilepsy as large cerebral infarction involving cerebral cortex and intracerebral hemorrhage, there are growing evidences of roles of subcortical infarction, chronic subdural hematoma, and superficial siderosis of the central nervous system in the pathogenesis of epilepsy. We review here the epidemiology and possible predictors of epilepsy in each type of cerebrovascular lesions and summarize the characteristics of semiology and electroencephalography findings in order to take early treatment strategy. Additionally, relevance of acute-symptomatic seizures and status epilepticus to epilepsy is discussed.

show abstract

“…Of the 205 unduplicated records that were identified during our initial search, the full texts of 26 articles were reviewed. A total of 7 articles including 53,579 subjects met our inclusion criteria and were finally included in this systematic review [13,14,16,17,[22][23][24]. A flow chart of the selection procedure is demonstrated in Fig.…”

Section: Study Characteristics and Qualitative Assessmentmentioning

confidence: 99%

“…1. Of 7 studies, 5 were from the China [14,16,17,23,24], 1 from Japan [13], and 1 from Brazil [22]. Five studies had retrospective designs and two had prospective designs.…”

Section: Study Characteristics and Qualitative Assessmentmentioning

confidence: 99%