The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis

Han, Bing; Yan, Bo; Zhao, Na; Zhang, Jian; Sun, Jianhua; Lei, Xibing; Li, Chao; Liu, Hongbo; Chen, Jie

doi:10.1080/13607863.2013.788996

Cited by 18 publications

(21 citation statements)

References 23 publications

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“…BASDAI addresses disease activity which definitely affects quality of life, thereby, it is reasonable to draw such a conclusion. The conclusion is highly consistent with Bing Han’s research indicating functional capacity as predictor of psychological health [40], as well as the study of Geertzen which concluded that the influence on SWB was less when patients were physically independent [41]. Based on the findings of the present study, positive attitudes towards therapy prospect leads to higher well‑being of the patients with AS.…”

Section: Discussionsupporting

confidence: 92%

Analysis on the situation of subjective well-being and its influencing factors in patients with ankylosing spondylitis

Wang

Zhang

et al. 2016

Health Qual Life Outcomes

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BackgroundTo examine the subjective well-being (SWB) in patients with ankylosing spondylitis (AS) compared with the healthy controls, and to explore the associations between SWB and demographic characteristics, disease-specific variables in AS patients.MethodsSWB was assessed with General Well-Being Schedule (GWBS) in 200 AS patients and 210 healthy controls. Comparisons among subgroups were performed to investigate how certain aspects operate as favorable or adverse factors in influencing SWB in the patients with AS.ResultsBoth men and women with AS reported significantly impaired SWB on all scales of the GWBS except for the Control (O) scale. The results revealed that better sleep, lower disease activity and more family care predicted higher SWB. In AS patients, positive attitude towards therapy prospect was significantly associated with higher SWB. Therapy prospect refers to the hope of patients about the disease treatment.ConclusionsCompared with general population, SWB might be affected by the onset of AS. There are significant associations between SWB and sleep quality, BASDAI, APGAR, therapy prospect.

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Section: Discussionsupporting

confidence: 92%

Analysis on the situation of subjective well-being and its influencing factors in patients with ankylosing spondylitis

Wang

Zhang

et al. 2016

Health Qual Life Outcomes

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“…Two-sided χ 2 tests and Student’s t-tests were used to evaluate distribution differences in demographic characteristics as well as in environmental exposures between the cases and controls. Logistic regression analyses with adjustment for age, gender, silica dust exposure years and smoking status were employed to evaluate associations between CPM and CPSF6 genetic variants and the development of silicosis and to estimate ORs and 95% CIs.…”

Section: Methodsmentioning

confidence: 99%

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case–control study

Chu

Wang³

et al. 2019

Occup Environ Med

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ObjectivesIn a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.MethodsWe systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M (CPM) and cleavage and polyadenylation specific factor 6 (CPSF6)) in a case–control study including 177 cases with silicosis and 204 healthy controls, matched to cases with years of silica dust exposure. We evaluated the associations between these eight SNPs and the development of silicosis. Luciferase reporter gene assays were performed to test the effects of selected SNP on the activity of CPM in the promoter. In addition, a two-stage case–control study was performed to investigate the expression differences of the two genes in peripheral blood leucocytes from a total of 64 cases with silicosis and 64 healthy controls with similar years of silica dust exposure as the cases.ResultsWe found a strong association between the mutant rs12812500 G allele and the susceptibility of silicosis (OR=1.45, 95% CI 1.03 to 2.04, p=0.034), while luciferase reporter gene assays indicated that the mutant G allele of rs12812500 is strongly associated with increased luciferase levels compared with the wild-type C allele (p<0.01). Moreover, the mRNA (peripheral blood leucocytes) expression of the CPM gene was significantly higher in subjects with silicosis compared with healthy controls.ConclusionsThe rs12812500 variant of the CPM gene may increase silicosis susceptibility by affecting the expression of CPM, which may contribute to silicosis susceptibility with biological plausibility.

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“…As a result, the quality of life of these patients is impaired; however, few studies have evaluated the impact of the disease on the quality of life of patients with silicosis. [13][14][15] There is no specific health questionnaire for this disease. A recent study investigated the impact of silicosis on quality of life of Chinese patients by George's Respiratory Questionnaire; the study sample presented a relatively moderate impact on the respirationrelated quality of life.…”

mentioning

confidence: 98%

Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

Braz¹,

Carneiro

Avelar³

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.

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The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis

Cited by 18 publications

References 23 publications

Analysis on the situation of subjective well-being and its influencing factors in patients with ankylosing spondylitis

Analysis on the situation of subjective well-being and its influencing factors in patients with ankylosing spondylitis

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case–control study

Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica

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