The influence of visual ability on learning and memory performance in 13 strains of mice

Brown, Richard E.; Wong, Aimee A.

doi:10.1101/lm.473907

Cited by 166 publications

(124 citation statements)

References 68 publications

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“…Nevertheless, all models showed retinal alterations even at various extents that sometimes preceded the cerebral lesions and in all models, the alterations are prevalent in the inner layer (4)(5)(6)(7)14). This is of importance considering the role of the visual disturbances in evaluating the learning and the memory (65). In short, a frequent and sometimes early involvement of the visual system was demonstrated but new studies are needed in order to investigate the degree of the visual impairment and in the animal models, the importance of the visual deficits in evaluating the cognitive deficits.…”

Section: Discussionmentioning

confidence: 99%

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

Raudino

2018

Arch Neurosci

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Context: The retina is a part of the Central Nervous System that is easy to study. The visual disturbances are frequent in Alzheimer's disease (AD) patients and sometimes, the AD begins with visual symptoms. This paper aims to review the existing literature on the involvement of the eye in the AD. In this first part, the animal models and the pathology in humans were examined. Evidence Acquisition: The Medline literature until March 2018 was surveyed. Results: Both animal models and pathological studies in humans demonstrate the impairment of the visual system in the AD, often in the early stages. Conclusions: A frequent and sometimes early involvement of the visual system was demonstrated but new studies are needed in order to investigate the degree of the visual impairment and in the animal models, the importance of the visual deficits in evaluating the cognitive deficits.

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Section: Discussionmentioning

confidence: 99%

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

Raudino

2018

Arch Neurosci

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“…All testing was performed with odours as conditioned stimuli, considering the ability of mice to discriminate even slight differences between odours [40]; this ability is also found in individuals of the BALB/c and the 129S1/SvImj sub-strain [41]. Odour mixtures have been used before in a judgement bias experiment with honeybees [17].…”

Section: Behavioural Testingmentioning

confidence: 99%

A test to identify judgement bias in mice

Boleij

Klooster

Lavrijsen

et al. 2012

Behavioural Brain Research

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“…Yet almost every medical school has a behavior core churning out data from the same discredited methods. Ignorance of basic behavioral methodology has led to essential quality controls being sacrificed in the interest of throughput and automation, the result being garbage in, garbage out 17,18,29,30,36,38,45 .…”

Section: What Features Of the Measures Are Ignored?mentioning

confidence: 99%

“…Nowhere is this more true than behavioral phenotyping -an ethologist attempting to do genetic work without genetics expertise would never survive peer review, but the behavioral genetics literature is characterized by geneticists assessing behavioral phenotypes with no behavioral training 88 . Accordingly, the majority of behavioral phenotyping tasks have been thoroughly discredited by ethologists and experimental psychologists 29,30,36,38,45 (for a comprehensive review, see refs. 17,18).…”

Section: What Features Of the Measures Are Ignored?mentioning

confidence: 99%

“…17,18,26-28,39,41) do not represent a voice in the wilderness, but one voice in a chorus and that this emerging literature 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]42,43 reflects a nascent discipline which can be codified as the study of how knowledge is gained from animal research. We propose the title "Therioepistemology" This focus issue of Lab Animal coincides with a tipping point in biomedical research.…”

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confidence: 99%

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Introducing Therioepistemology: the study of how knowledge is gained from animal research

et al. 2017

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We are honored to write the opening article of this focus issue of Lab Animal. This focus issue could not occur at a more important time for biomedical research and the use of animals in science in general. The progressive worsening of success rates in human trials (currently 1 in 9 drugs entering human trials will succeed) 1-4 , combined with the explosion of interest in the reproducibility crisis 5-8 and the recognition that most drugs fail in human trials due to insufficient efficacy 1,2,4 , has led to a growing suspicion that the failure of translation from animal work to human outcomes may in some way reflect issues in animal research itself 5-19 -after all, every drug that fails in humans "worked" in an animal model. Indeed pharmaceutical companies continue to disinvest in internal animal R&D, a trend begun in the last decade, passing on the cost and risk to academia and startups 5,20 . Even this approach is not foolproof as pharmaceutical companies often cannot replicate the results of published work from academia 5,8,13 . Accordingly, there is a growing trend to focus on human, not animal, work for basic discovery 17 .Discarding animal research entirely is not the answer. When properly used, animal models have incredible value, not least the ability to follow biomarkers from birth to disease onset in a year or less (in the case of mice), which is impossible in humans 17,18 . There are patterns and principles that can help us identify models and results that are more or less likely to translate, and there are also easily realized, simple changes in the execution of animal work that will inherently improve translation [16][17][18] . This isn't a new concept; looking back over the last 10-15 years we can see many authors have been candid about the merits, strengths, weaknesses, reproducibility, and translatability of various animal models 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Our goal with this article is to unite the common themes in this broader emerging literature and this special issue.Thus, the central point is that we (i.e., refs. 17,18,26-28,39,41) do not represent a voice in the wilderness, but one voice in a chorus and that this emerging literature 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]42,43 reflects a nascent discipline which can be codified as the study of how knowledge is gained from animal research. We propose the title "Therioepistemology" This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the first time, the scale of the reproducibility and translatability crisis is widely understood beyond the small cadre of researchers who have been studying it and the pharmaceutical and biotech companies who have been living it. Here we argue that an emerging literature, including the papers in this focus issue, has begun to congeal around a set of recurring themes, which themselves represent a paradigm shift. This paradigm shift can be c...

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The influence of visual ability on learning and memory performance in 13 strains of mice

Cited by 166 publications

References 68 publications

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

Ocular and Visual Manifestation of the Alzheimer’s Disease: A Literature Review, Part I: Animal Models and Human Pathology

A test to identify judgement bias in mice

Introducing Therioepistemology: the study of how knowledge is gained from animal research

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