The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

Costa-Martins, José Manuel; Pereira, Marco; Martins, Humberto; Moura­‐Ramos, Mariana; Coelho, Rui; Tavares, João Manuel Ribeiro da Silva

doi:10.3109/07420528.2014.901973

Cited by 8 publications

(14 citation statements)

References 56 publications

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“…Many patients with rheumatoid arthritis (RA) present a circadian rhythm in the severity of symptoms, with a significant worsening in the morning. Previous studies have shown that the change of pain threshold has an obvious circadian rhythm [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture

Liu

Zhao

Zhou

et al. 2020

Pain Research and Management

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Objective. The aim of this study was to demonstrate the peripheral mechanisms of chrono-acupuncture by observing acupuncture at different time points affecting relative proteins to regulate the cytoskeleton of fibroblasts differently. Methods. A total of 108 male SD rats (180–220 g) that have basic pain threshold within 3–10 s were selected and randomly divided into group A (n = 72) and control group (n = 36). After the succession of modeling with CFA injection, the rats in group A were randomly divided into model group and acupuncture group, each group containing 36 rats. Then according to the different treatment time, each group was randomly classified into 6 subgroups (ZT0, ZT4, ZT8, ZT12, ZT16, and ZT20), each subgroup containing 6 rats (n = 6). On the second day of successful modeling, the rats in the acupuncture group received acupuncture treatment at the corresponding time point, while the control group and the model group were only tied up at the corresponding time point without any treatments. Methods of operation: use 0.5-inch needles, puncture the rats’ “Zusanli” on the affected limb, with Twirling manipulation for a minute after every five minutes; the treatment lasts thirty minutes in total. After 7 days of treatments, the skin and subcutaneous tissue of rats’ acupoint area of “Zusanli” on the affected limb were taken and then stained by immunofluorescence double staining method to observe the expression of the fibroblast cytoskeleton F-actin and β-tubulin under the LSCM while using western blot to observe the expression of P38MAPK/P-P38MAPK. Results. The expression of the cytoskeleton F-actin and β-tubulin at acupoint area in the acupuncture group was significantly higher than that in the control and model group. The effect of acupuncture on the restructure of the fibroblast cytoskeleton is different at different time points, the most effective time point was at ZT12 while the least at ZT16. Acupuncture can decrease the high expression of P-P38MAPK/P38MAPK in the model group, and the effect has time differences. The expression of P-P38MAPK/P38MAPK increased more significantly at ZT16 than ZT12. Conclusion. The remodeling difference of fibroblast cytoskeleton after receiving acupuncture treatment could be one of the peripheral bases of the chrono-acupuncture.

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Section: Introductionmentioning

confidence: 99%

The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture

Liu

Zhao

Zhou

et al. 2020

Pain Research and Management

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“…Debon et al 5 observed significantly longer effect of epidural ropivacaine during the first stage of labour in the diurnal period. Costa-Martins et al 6 , using patient-controlled epidural analgesia, observed longer pharmacological effect during daytime and longer latency period at night. Chassard et al 7 found temporal pattern in the duration of intrathecal plain bupivacaine with a 25% variation during daytime, with a peak around noon.…”

Section: Discussionmentioning

confidence: 97%

“…[1][2][3][4] In order to establish if neuraxial local anaesthetics present time-dependent effects, numerous chronobiological studies were conducted in labour pain analgesia. [5][6][7][8]13 Although only two studies reported that time of day did not appear to influence the duration of analgesia during labour produced by intrathecal local anaesthetics or opioids 9,10 , the results of most studies were able to produce a consistent picture with peaks in the morning or at noon. 4,5,7,8 The pharmacological effect regarding intrathecal or epidural administration of local anaesthetics was longer in the diurnal period 4,8,13 , and the latency period was longer at night 6 .…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8]13 Although only two studies reported that time of day did not appear to influence the duration of analgesia during labour produced by intrathecal local anaesthetics or opioids 9,10 , the results of most studies were able to produce a consistent picture with peaks in the morning or at noon. 4,5,7,8 The pharmacological effect regarding intrathecal or epidural administration of local anaesthetics was longer in the diurnal period 4,8,13 , and the latency period was longer at night 6 . A temporal pattern in the duration of analgesia with a peak around noon 5,7,8 was also observed.…”

Section: Introductionmentioning

confidence: 99%

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Circadian effects on neural blockade of levobupivacaine and fentanyl intrathecal administration for caesarian section

Nikouli¹,

Chloropoulou²,

Karras³

et al. 2022

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Introduction: Circadian variations in biological rhythms affect the pharmacological properties of many anaesthetic agents, suggesting circadian patterns of local anaesthetics’ activity in labour pain analgesia, with important differences among diurnal and nocturnal phases. Aim: We examined whether a rhythmic variation of the effect of intrathecal mixture of levobupivacaine and fentanyl exists throughout the day period regarding caesarean sections.  Materials and methods: Eighty parturients presented for caesarean section, both urgent and/or elective, were assigned to five equal groups (A, B, C, D, and E) according to the time-point of the intrathecal drug administration. The same levobupivacaine and fentanyl dose was given to all patients. Pinprick or cold test, the four-point modified Bromage scale (0-3), and the numerical scale (NRS 0-10) were used respectively for the assessment of sensory and motor blockade, and post-anaesthetic pain. The duration of sensory and motor blockade, analgesia duration and pain score at first analgesic request were recorded. Results: Statistically significant differences were found among the studied groups in the duration of motor and sensory blockade and pain score at first postoperative analgesic request. Prolonged duration of motor blockade in groups A, B and C (p<0.001) and prolonged duration of sensory blockade and analgesia in groups A, B (p<0.001) were observed. Higher pain scores at first postoperative analgesic request were recorded in group Ε (p<0.001).  Conclusions: The present study highlights the significant effects of circadian rhythm on the efficacy of a mixture of local anaesthetics, levobupivacaine and fentanyl, during caesarean delivery.

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“…many patients with RA present a circadian rhythm in symptoms severity with a significant worsening in Journal of Complementary Medicine & Alternative Healthcare the morning. Additionally, studies have shown that the change of pain threshold had obvious circadian rhythm [5][6]. It has been recognized that acupuncture, as an effective means of treatment, could relieve various kinds of pain syndromes [7][8].…”

Section: Introductionmentioning

confidence: 99%

The Roles of Extracellular Purinergic Signaling in Local Acupoints In ChronoAcupuncture Analgesia

2019

JCMAH

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Objective: To explore the peripheral mechanism of chrono-acupuncture with respect to purinergic signaling in local acupoints. Methods:The Sprague Dawley (SD) rats were randomly divided into two groups. One group was injected 0.1ml saline as control group. Another group was established by subcutaneous injecting 0.1ml complete Freund's adjuvant (CFA). After modeling successfully, model rats were randomly divided into model group and acupuncture group based on the basic pain threshold. The basic pain threshold was tested by tailflick method. The extracellular ATP concentration in local acupoints was detected by high-performance liquid chromatography (HPLC) after acupunctured at different times, which were zeitgeber time 0(ZT0) (7:00), ZT4(11:00), ZT8(15:00), ZT12(19:00), ZT16(23:00), and ZT20(3:00) respectively. Based on the characteristics of the variation of pain threshold and extracellular ATP concentration, the peak phase and valley phase were selected for the further experiment. The protein expression of P2X3 receptors in skin of "Zusanli" (ST36), dorsal root ganglion (DRG) and spinal dorsal horn (SDH) were separately detected by immunohistochemistry.Results: Time had an evident influence on pain threshold (P=0.047, P<0.05) which indicated the pain threshold at different time points was different. The variation of pain threshold among control group, model group and acupuncture group were significantly different (P<0.01). In acupuncture group, the of peak value and valley value appeared at ZT8 and ZT16 respectively. Pain threshold showed complex interactions with extracellular ATP, time factor and acupuncture stimuli. The extracellular ATP concentrations were significantly different in comparison among control group, model group and acupuncture group respectively. (P<0.01). As for protein expression of P2X3 receptors in skin of "Zusanli" (ST36), compared with control group, it obviously increased in model group at ZT8 and ZT16. And there was significant difference between control group and model group (P<0.01). In addition, compared with model group, it obviously decreased after acupunctured at ZT8. And there was significant difference between model group and acupuncture group at ZT8(P<0.01), but not at ZT16 (P>0.05). Interestingly, the protein expression of P2X3 receptors in both DRG and SDH was consistent with that in skin of "Zusanli" (ST36). Conclusion:Temporal variation of purinergic signaling participated in the initial mechanism of chrono-acupuncture analgesia in local acpoints. Also, that might be the base of dynamic variation of acupoints reactivity.

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The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

Cited by 8 publications

References 56 publications

The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture

The Roles of Skin Fibroblasts at Local Acupoints in Chrono-Acupuncture

Circadian effects on neural blockade of levobupivacaine and fentanyl intrathecal administration for caesarian section

The Roles of Extracellular Purinergic Signaling in Local Acupoints In ChronoAcupuncture Analgesia

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