The information theory of aging: The major factors that determine lifespan

Карнаухов, А. В.; Karnaukhova, E. V.; Sergievich, L. A.; Karnaukhova, N. A.; Богданенко, Е. В.; Manokhina, Irina; Karnaukhov, V. N.

doi:10.1134/s0006350917050098

Cited by 5 publications

(7 citation statements)

References 22 publications

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“…Our approach differs from many other in the usage of a renormalization calculation of climate model parameters that allows to explicitly include water vapor feedback [7] that is "typically neglected" [8]. Not only this increases the value of MAT, but does also lengthen the relaxation time required for the temperature curve leveling off.…”

Section: Inroductionmentioning

confidence: 99%

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Non-steady state model of global temperature change: Can we keep temperature from rising more than on two degrees?

Karnaukhov,

Karnaukhova,

Popova

et al. 2021

Preprint

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We propose a non-steady state model of the global temperature change. The model describes Earth's surface temperature dynamics under main climate forcing. The equations were derived from basic physical relationships and detailed assessment of the numeric parameters used in the model. It shows an accurate fit with observed changes in the surface mean annual temperature (MAT) for the past 116 years. Using our model, we analyze the future global temperature change under scenarios of drastic reductions of CO 2 . The presence of non-linear feed-backs in the model indicates on the possibility of exceeding two degrees threshold even under the carbon dioxide drastic reduction scenario. We discuss the risks associated with such warming and evaluate possible benefits of developing CO 2 -absorbing deciduous tree plantations in the boreal zone of Northern Hemisphere.

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Section: Inroductionmentioning

confidence: 99%

“…Using expressions (4a) and (4b) for W S in (t 0 ) and W T out (t 0 ) and considering that the changes of these corresponding parameters are small, we may present (7) as:…”

Section: B Derivation Of the Non-steady State Model Main Equations Of...mentioning

confidence: 99%

Non-steady state model of global temperature change: Can we keep temperature from rising more than on two degrees?

Karnaukhov,

Karnaukhova,

Popova

et al. 2021

Preprint

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“…The concept of information in biology has a long history [ 28 ], and biological systems can be seen as highly complex information systems. Likewise, the idea that ageing could be linked to information decay or loss has been proposed, in particular in the context of the information theory of ageing [ 29 – 31 ]. According to this theory, loss of genetic [ 29 ] or epigenetic [ 30 , 31 ] information with age, driven by DNA damage, is the primary cause of ageing.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, the idea that ageing could be linked to information decay or loss has been proposed, in particular in the context of the information theory of ageing [ 29 – 31 ]. According to this theory, loss of genetic [ 29 ] or epigenetic [ 30 , 31 ] information with age, driven by DNA damage, is the primary cause of ageing. One hypothesis is that errors accrue in the DNA, corrupting the information in the genome and ultimately disrupting tissue homeostasis and causing ageing [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Ageing as a software design flaw

Magalhães

2023

Genome Biol

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Ageing is inherent to all human beings, yet why we age remains a hotly contested topic. Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of one or more forms of molecular damage. Here, I propose that we age not because of inevitable damage to the hardware but rather because of intrinsic design flaws in the software, defined as the DNA code that orchestrates how a single cell develops into an adult organism. As the developmental software runs, its sequence of events is reflected in shifting cellular epigenetic states. Overall, I suggest that to understand ageing we need to decode our software and the flow of epigenetic information throughout the life course.

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“…Using the example of changes in epithelial structure, we will show how Kullback-Leibler entropy grows. Variants of Karnaukhov's [17][18][19][20][21][22] and Sinclair's [23,24] information theories of aging will also be discussed (for a common issue, see [25]). These representations will hopefully allow us to develop a new approach to the experimental estimation of the biological age of a system.…”

Section: Introductionmentioning

confidence: 99%

The Degradation and Aging of Biological Systems as a Process of Information Loss and Entropy Increase

Аристов

Карнаухов

Buchelnikov

et al. 2023

Entropy

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The problem of the degradation and aging of bioorganisms is herein considered from the viewpoint of statistical physics. Two typical timescales in biological systems—the time of metabolic processes and the time of the life cycle—are used. A kinetic equation describing the small timescales of the systems’ characteristic processes in is proposed. Maintaining a biosystem in a time-stable state requires a constant inflow of negative entropy (negentropy). Ratios are proposed to evaluate the aging and degradation of systems in terms of entropy. As an example, the aging of the epithelium is studied. The connection of our approach to the information theory of aging is discussed, as well as theoretical constructions related to the concept of cooperon and its changing with time.

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The information theory of aging: The major factors that determine lifespan

Cited by 5 publications

References 22 publications

Non-steady state model of global temperature change: Can we keep temperature from rising more than on two degrees?

Non-steady state model of global temperature change: Can we keep temperature from rising more than on two degrees?

Ageing as a software design flaw

The Degradation and Aging of Biological Systems as a Process of Information Loss and Entropy Increase

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