The Inheritance of Slipped Upper Femoral Epiphysis

Rennie, A. M.

doi:10.1097/01241398-198208000-00039

Cited by 11 publications

(11 citation statements)

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“…This pair of brothers was the only patients we had who had any significant family history of note. In the literature, SCFE has been reported to be a disease with autosomal dominant inheritance pattern with variable penetrance [12].…”

Section: Endocrine Problems and Obesitymentioning

confidence: 99%

Demographics and clinical presentation of slipped capital femoral epiphysis in Singapore: comparing the East with the West

Lim

Kagda

Lam

et al. 2008

Journal of Pediatric Orthopaedics B

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This study examines the demographics and clinical presentation of slipped capital femoral epiphysis in Singapore. Sixty-six patients (53 boys, 13 girls) with 77 involved hips were reviewed retrospectively. Local prevalence was 1.2/100,000 children. Twenty-four patients were Chinese, 12 were Malay, 27 were Indians, and three patients were Eurasians. A total of 76.6% of patients above the 90th percentile for body weight were present; 16.7% of patients had bilateral involvement. Seventeen patients had endocrine-related problems. We had a high male preponderance, and a disproportionately high number of Indian patients. A high proportion of patients were obese. Our incidence of bilateral involvement seems to be higher than our Indonesian neighbors. The differences seen may be due to genetic and sociocultural variations.

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Section: Endocrine Problems and Obesitymentioning

confidence: 99%

Demographics and clinical presentation of slipped capital femoral epiphysis in Singapore: comparing the East with the West

Lim

Kagda

Lam

et al. 2008

Journal of Pediatric Orthopaedics B

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“…3,4 They also noted that Polynesian children (4.5 times higher incidence rates) and black children (2 times higher incidence rates) have a higher relative incidence rate of SCFE than white children, whereas Indonesian-Malay (0.5 times the incidence rate) and Indo-Mediterranean (0.1 times the incidence rate) have lower relative frequencies of SCFE than white children. 2 These differences indicate a direct correlation between the average weight of a race and the incidence of SCFE.…”

mentioning

confidence: 92%

The Epidemiology of Slipped Capital Femoral Epiphysis

Lehmann¹,

Arons²,

Loder³

et al. 2006

Journal of Pediatric Orthopaedics

313

230

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The Kids' Inpatient Database, reflecting 6.70 million pediatric discharges in 1997 and 7.30 million in 2000, was coupled with the US Census Bureau data and was used to elicit the epidemiology of idiopathic slipped capital femoral epiphysis (SCFE) that occurred in children 9-16 years. It was found that the overall incidence of SCFE in the United States for these years was 10.80 cases/100,000 children. The relative incidence of SCFE was 3.94 times higher in black children and 2.53 times higher in Hispanic children than in white children. The incidence rate was significantly higher in boys (13.35 cases/100,000 children) than in girls (8.07 cases/100,000 children). Higher incidence rates of SCFE were found in the Northeast and West when compared with rates in the Midwest and the South, suggesting that climate plays a role in the onset of SCFE. Increased incidence of SCFE was noted north of 40 degrees latitude during the summer and south of 40 degrees latitude during the winter. Age of onset was also lower than previously reported and seems to be on a downward trend. This study suggests that the relative incidences of SCFE in blacks and Hispanics are higher than previously reported in the United States. Geographic, racial, and seasonal variations suggest that both environmental and genetic factors may influence the development of SCFE.

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“…Whether this is due simply to a genetic predisposition or due to a tendency to other risk factors (such as obesity) remains unclear. Rennie 21 showed that the risk of a SUFE in a second family member was 7.1% and that 14.5% of SUFE patients had a close family member who also had the disorder. There may be an association with HLA markers, such as DL4 or B12 but again this is unclear.…”

Section: Other Factorsmentioning

confidence: 98%