The inhibitory effect of circulating lymphocytes on granulopoiesis in human cyclic neutropenia in vitro.

Inoue, M.; Yamada, Katsunori; Ishida, Yoshiteru; Shinohara, Kenji; Kaneko, Takeshi; Matsumoto, Noboru

doi:10.1620/tjem.143.213

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…A population of clonal large granular lymphocytes is described in adult-onset cyclic neutro penia, and it has been hypothesized that a benign neoplastic expansion of these may cause the cycling [12]. Others suggest an inhibitory [13] role for mono nuclear cells in this disorder. Grey collie cyclic neu tropenia, a naturally occurring canine variant, is asso ciated with oscillations in endogenous granulocyte colony-stimulating factor (G-CSF) levels.…”

Section: Discussionmentioning

confidence: 99%

Acquired Cyclic Haematopoiesis Associated with a Radiation-Induced Chromosomal Abnormality with Clonal, Morphologically Normal Circulating Leucocytes

et al. 1991

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A 62-year-old male with a history of vesical carcinoma treated with pelvic radiotherapy and cystectomy developed intermittent fevers associated with oral ulcers and neutropenia. Serial blood counts revealed cyclic haematopoiesis, with periodic neutropenia, lymphocytopenia, monocytopenia and thrombocytopenia. Bone marrow examination revealed intermittent hypoplasia without myelodysplasia or leukaemia. Marrow karyotype revealed a clonal chromosomal abnormality which included trisomy 8 and absence of the Y chromosome. We also provide evidence of spontaneous differentiation of the clonal marrow cells to mature leucocytes.

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Section: Discussionmentioning

confidence: 99%

Acquired Cyclic Haematopoiesis Associated with a Radiation-Induced Chromosomal Abnormality with Clonal, Morphologically Normal Circulating Leucocytes

et al. 1991

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“…Granulocyte-macrophage colony-forming unit (CPU-GM) assay using bone marrow MNC was performed according to a previously de-scribed method (Inoue et al 1984). Normal bone marrow cells (2 X 105/ml) were co-cultured with and without the patient's serum or MNC-CM at final concentrations of 10%.…”

Section: Preparation Of Mononuclear Cell-conditioned Mediummentioning

confidence: 99%

A Case Report of Familial Cyclic Neutropenia.

Inoue

Tani

Tajiri

et al. 1992

Tohoku J. Exp. Med.

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Adult‐onset cyclic bicytopenia: A case report and review of treatment of cyclic hematopoiesis

Tefferi¹,

Solberg²,

Petitt³

et al. 1989

American J Hematol

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A unique case of adult-onset synchronous cyclic neutropenia and thrombocytopenia occurring at six-week intervals is presented. Periods of cytopenia were associated with fever, myalgias, gastrointestinal symptoms, and mild mucocutaneous bleeding. Alternate-day steroid treatment failed to correct the periodic fluctuations in peripheral blood counts but ameliorated symptoms during cytopenia. The treatment of cyclic hematopoiesis is reviewed.

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The inhibitory effect of circulating lymphocytes on granulopoiesis in human cyclic neutropenia in vitro.

Cited by 5 publications

References 27 publications

Acquired Cyclic Haematopoiesis Associated with a Radiation-Induced Chromosomal Abnormality with Clonal, Morphologically Normal Circulating Leucocytes

Acquired Cyclic Haematopoiesis Associated with a Radiation-Induced Chromosomal Abnormality with Clonal, Morphologically Normal Circulating Leucocytes

A Case Report of Familial Cyclic Neutropenia.

Adult‐onset cyclic bicytopenia: A case report and review of treatment of cyclic hematopoiesis

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