The Insect Central Nervous System as a Site of Action of Neurotoxicants

Sattelle, David B.

doi:10.1007/978-1-4615-8834-4_3

Cited by 13 publications

(2 citation statements)

References 56 publications

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“…Using the metathoracic ganglion of the same insect, Carr & Fourtner (1980) have shown that 10 X 10~7M a-bungarotoxin blocks synapses between trochanteral hairplate afferents and a leg motoneurone (D 8 ). There is considerable pharmacological evidence that acetylcholine is the likely transmitter molecule at all these synapses (Shankland, et al 1971;Callec, 1974;Sattelle, McClay, Dowson & Callec, 1976;Sattelle, 1978;Carr & Fourtner, 1980).…”

Section: Discussionmentioning

confidence: 99%

α-Bungarotoxin Blocks Excitatory Synaptic Transmission Between Cercal Sensory Neurones and Giant Interneurone 2 of the Cockroach,Periplaneta Americana

Sattelle

Harrow

Hue

et al. 1983

Journal of Experimental Biology

109

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1. Autoradiographic localization of an 125I-α-bungarotoxin binding component revealed that specific binding was distributed mainly in the neuropile and to some extent in the periphery of the terminal abdominal ganglion of the cockroach, Periplaneta americana (L.). 2. Action potentials recorded from the axon of GI2 under current-clamp conditions were not affected by exposure to 1.0×10−5M α-bungarotoxin. 3. Excitatory postsynaptic potentials recorded from GI2, evoked by stimulation of cereal sensory neurones, were sensitive to block by relatively low concentrations (1.0×10−9-1.0×10−7 M) of α-bungarotoxin. The time-course for blockade was found to depend on toxin concentration and frequency of afferent stimulation. 4. Excitatory postsynaptic potentials recorded from GI 2 were not affected by exposure to 1.0×10−6M quinuclidinyl benzilate. 5. We conclude that at least a portion of the 125I-α-bungarotoxin binding component represents cholinergic receptors which have a postsynaptic function at synapses between cereal sensory neurones and GI 2.

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Section: Discussionmentioning

confidence: 99%

α-Bungarotoxin Blocks Excitatory Synaptic Transmission Between Cercal Sensory Neurones and Giant Interneurone 2 of the Cockroach,Periplaneta Americana

Sattelle

Harrow

Hue

et al. 1983

Journal of Experimental Biology

109

View full text Add to dashboard Cite

show abstract

“…Evidence for this was also provided by the experiments-with SKF 525A, an inhibitor of MFD systems. When DNIO, isofenphos oxon, and DNI were added to preparations pre treated with SKF 525A, these compounds were less active ( shown that this synapse is cholinergic for at least some of the GIs (Shankland et al, 1971;Callec, 1974;Sattelle et al, 1976;Sattelle, 1978;. Studies using modifications of the oil-gap technique, have shown that the carbamate eserine potentiates the effect of acetylcholine application to the sixth abdominal ganglion (A6) and also prolongs the EPSP at the cercal-to-GI synapse (Callec, 1974).…”

Section: Ecj2 Values and Cholinesterase Activitymentioning

confidence: 99%