The insertion/deletion (I/D) polymorphism in the angiotensin‐converting enzyme gene and erectile dysfunction risk: a meta‐analysis

Abstract

SUMMARYErectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of the relationship, a meta-analysis was conducted using data published previously by other groups. A total of six case-control studies, including 1039 cases and 927 controls, were selected. The pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) were calculated by comparing the carriers of D-allele with the wild homozygotes (ID + DD vs. II). Comparisons of other genetic models were also performed (ID + II vs. DD, DD vs. II, DI vs. II and D vs. I). In the overall analysis, no significant association between the polymorphism and ED risk was observed (OR=1.07, 95% CI = 0.84 À 1.37, p = 0.575 for ID + DD vs. II). In the subgroup analysis by ethnic, no significant association was detected among Asian, Latino and European for the comparison of ID + DD vs. II (Asian: OR=1.27, 95% CI = 0.89 À 1.81; Latino: OR=0.76, 95% CI = 0.46 À 1.27; European: OR=1.06, 95% CI = 0.67 À 1.66). Results from other comparative genetic models also indicated the lack of associations between this polymorphism and ED risk. In conclusion, this meta-analysis indicates that the ACE I/D polymorphism might not contribute to the risk of ED.

Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

“… 29 However, a meta-analysis including 1039 ED patients and 927 healthy controls concluded that the D polymorphism in the ACE gene was not associated with an increased risk of ED. 30 In addition to eNOS and ACE, the prevalence of the MTHFR 677TT polymorphism is higher in patients with vascular ED than that in those without vascular ED (15.8% vs 11.4%). 10 Mutation of MTHFR with the C to T substitution at nucleotide 677 causes the impairment of vascular smooth muscle cell and endothelial cell function by increasing plasma Hcy levels and intima-media thickening by decreasing blood flow in the erectile tissue of the corpora cavernosa.…”

Risk factors for erectile dysfunction: known and unexpected facts (review)

“…Связи между этими факторами также не было выявлено в разных этнических группах (азиаты, латиноамериканцы и европейцы). По данным метаанализа, полиморфизм гена ACE (I / D) не связан с риском ЭД [30].…”