The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysis

Abstract

BackgroundThe insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the ACE gene and cancer risk by meta-analysis.MethodsA search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.ResultsA total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.ConclusionsThis meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of cancer.

Lack of any Association between Insertion/Deletion (I/D) Polymorphisms in the Angiotensin-converting Enzyme Gene and Digestive System Cancer Risk: a Meta-analysis

“…Sensitivity analysis was analyzed as previous study (Zhang, 2011). Briefly, after excluding each case-control study for DD+DI vs. II comparison, statistically similar results were obtained, suggesting the results of this metaanalysis are stable.…”

“…Publication bias was assessed by using Begg's funnel plots and Egger's test. Sensitivity analysis was performed to assess the stability of the results by sequentially excluding each study (Zhang et al, 2011). All analyses were performed using the software Revman5.2 and STATA 12.0.…”

“…This polymorphism is based on insertion or deletion of a 287-bp Alu sequence, leading to a change in the plasma ACE level. Zhang et al have recently conducted a meta-analysis and found there no association between the ACE polymorphism and cancer risk (Zhang et al, 2011), but there were a few studies about the digestive system tumors. Recently several new studies have been published to investigate the associations between this polymorphism and digestive system cancer risks; the results were inconsistent and conflict.…”

The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease

“…The human ACE gene is located on chromosome 17q23, spans 21 kb, and comprises 26 exons and 25 introns (Berdeli and Cam, 2009;Zhang et al, 2011). The most widely studied polymorphism, an insertion/deletion (I/D, rs4646994), is located in intron 16.…”

“…Angiotensin I-converting enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS), plays an important role in the regulation of blood pressure and serum electrolyte levels (Berdeli and Cam, 2009;Zhang et al, 2011). ACE is a component of the systemic and tissue RAS, which play an important role in the regulation of blood pressure, sodium and water homeostasis, and tissue growth.…”