The insular lobe in primates including humans

Augustine, James R.

doi:10.1080/01616412.1985.11739692

Cited by 209 publications

(124 citation statements)

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“…These findings not only extend previous recordings in the insula which relied on simplistic stimuli (Pribram et al, 1954;Sudakov et al, 1971;Bieser and Müller-Preuss, 1996;Bieser, 1998) but are also in good agreement with results from human imaging and lesion studies, which implicate the insula in the processing of complex sounds and speech (Augustine, 1985;Bamiou et al, 2003). Given the structural similarity of the insula and auditory pathways across humans and monkeys, our findings have direct implications on the mechanisms operating in the human brain (Hackett et al, 2001;Chiry et al, 2003;Sweet et al, 2005;Ghazanfar, 2008).…”

Section: An Auditory Region In the Insulasupporting

confidence: 79%

“…Imaging studies implicate the insula in processing simple sounds and rhythms (Griffiths et al, 1997;Herdener et al, 2008) and vocal communication signals (Zatorre et al, 1994;Rumsey et al, 1997;Meyer et al, 2002;Kotz et al, 2003;Wong et al, 2004;Sander and Scheich, 2005) (and see Augustine, 1985;Bamiou et al, 2003). In addition, insula lesions often manifest as deficits in sound or speech recognition (auditory agnosia) and speech production (Spreen et al, 1965;Cancelliere and Kertesz, 1990;Engelien et al, 1995;Habib et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

Remedios¹,

Logothetis²,

Kayser³

2009

J. Neurosci.

131

100

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Human imaging studies implicate the insular cortex in processing complex sounds and vocal communication signals such as speech. In addition, lesions of the insula often manifest as deficits in sound or speech recognition (auditory agnosia) and speech production. While models of acoustic perception assign an important role to the insula, little is known about the underlying neuronal substrate. Studying a vocal primate, we identified a predominantly auditory region in the caudal insula and therein discovered a neural representation of conspecific communication sounds. When probed with natural sounds, insula neurons exhibited higher response selectivity than neurons in auditory cortex, and in contrast to these, responded preferentially to conspecific vocalizations. Importantly, insula neurons not only preferred conspecific vocalizations over a wide range of environmental sounds and other animal vocalizations, but also over acoustically manipulated versions of these, demonstrating that this preference for vocalizations arises both from spectral and temporal features of the sounds. In addition, individual insula neurons responded highly selectively to only a few vocalizations and allowed the decoding of sound identity from single-trial responses. These findings characterize the caudal insula as a selectively responding auditory region, possibly part of a processing stream involved in the representation of communication sounds. Importantly, our results provide a neural counterpart for the human imaging and lesion findings and uncover a basis for a supposed role of the insula in processing vocal communication sounds such as speech.

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Section: An Auditory Region In the Insulasupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

Remedios¹,

Logothetis²,

Kayser³

2009

J. Neurosci.

131

100

View full text Add to dashboard Cite

show abstract

“…Based on these findings, there has been speculation that the insula is involved in certain aspects of speech and language (Augustine, 1985). Additionally, the insula is involved in other perceptual-motor functions such as feeding behaviours, interoception (i.e., internal monitoring of bodily states), and also autonomic processes (e.g., respiratory control).…”

Section: Introductionmentioning

confidence: 99%

The role of the insula in speech and language processing

2014

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Lesion and neuroimaging studies indicate that the insula mediates motor aspects of speech production, specifically, articulatory control. Although it has direct connections to Broca's area, the canonical speech production region, the insula is also broadly connected with other speech and language centres, and may play a role in coordinating higher-order cognitive aspects of speech and language production. The extent of the insula's involvement in speech and language processing was assessed using the Activation Likelihood Estimate (ALE) method. Meta-analyses of 42 fMRI studies with healthy adults were performed, comparing insula activation during performance of language (expressive and receptive) and speech (production and perception) tasks. Both tasks activated bilateral anterior insulae. However, speech perception tasks preferentially activated the left dorsal mid-insula, whereas expressive language tasks activated left ventral mid-insula. Results suggest distinct regions of the mid-insula play different roles in speech and language processing.

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“…The insula (for review see [21,22]) is one of the paralimbic structures and constitutes the invaginated portion of the cerebral cortex, forming the base of the sylvian fissure. The insular cortex has been considered limbic sensory cortex by some investigators [23].…”

Section: Neural Systems Relevant For Anxiety Disordersmentioning

confidence: 99%

The role of neuroimaging for the diagnosis and treatment of anxiety disorders

Paulus

2008

Depress. Anxiety

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Neuroimaging comprises a set of tools, which include different types of magnetic resonance imaging such as fMRI, MRS, ASL, and radiotracer imaging such as PET and SPECT. The focus of this review is to address the question whether functional magnetic resonance imaging (fMRI) can contribute to the diagnosis and treatment of anxiety disorders. Key anxiety processes and neural substrates are reviewed. The main findings and shortcomings of fMRI in the context of anxiety are briefly summarized. Finally, the next stages of developing fMRI for diagnosis and treatment are highlighted. The main conclusion of this review is that fMRI could become a clinical tool for the diagnosis and treatment of anxiety disorders but neuroimaging groups will need to better develop its specificity and sensitivity so that fMRI results can be meaningful for an individual patient not just for groups of individuals. fMRI -what is it and what does it measure?Functional magnetic resonance imaging (fMRI) is a technique that enables one to map cognitive, affective, and experiential processes onto brain substrates. However, fMRI is not about increased or decreased activation in a certain part of the brain; rather it is a proxy measure about how complex cognitive, emotional, social and other experiential processes are implemented in different neural systems. For example, it is important to realize that it makes little sense to talk about hyperactivity in the amygdala in individuals with anxiety disorder without referencing the process, which is being measured during the amygdala hyperactivity, i.e. the task that individuals are engaged in while the functional images are obtained. Although the human brain comprises only about 2% of the body mass, it accounts for approximately 20% of its total oxygen consumption [1]. Deoxyhemoglobin has paramagnetic effects in the blood upon the nuclear magnetic resonance transverse relaxation times of nearby water protons in the tissue [2]. The fact that changes in the oxygen level in the blood can affect the fraction of hemoglobin in the deoxygenated state can be utilized as an image contrast and was termed as blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) [3]. Recent BOLD fMRI experiments in the awake Correspondence should be sent to: Martin P Paulus, Professor in Residence,

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The insular lobe in primates including humans

Cited by 209 publications

References 0 publications

An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

An Auditory Region in the Primate Insular Cortex Responding Preferentially to Vocal Communication Sounds

The role of the insula in speech and language processing

The role of neuroimaging for the diagnosis and treatment of anxiety disorders

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