The inter-relationship between gonadal steroids and POMC peptides, β-endorphin and α-MSH, in the control of sexual behavior in the female rat

Medina, Favio; Siddiqui, Anwar Ali; Scimonelli, Teresa Nieves; Fenske, Christine; Wilson, Catherine; Celis, Marı́a Ester

doi:10.1016/s0196-9781(98)00093-x

Cited by 26 publications

(16 citation statements)

References 34 publications

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“…As mentioned, the hippocampus is implicated in different functions, such as learning, memory, and sexual behavior (Medina et al, 1998;Feng et al, 2004;Daniel et al, 2005;Day and Good, 2005;Walf and Frye, 2008;Frick et al, 2010). In this brain area, estradiol induces the formation of excitatory synapses, increases dendritic spine density, synaptic plasticity, and prolongs excitatory postsynaptic potentials in CA1 pyramidal cells (Rudick and Woolley, 2001;Murakami et al, 2006;Mukai et al, 2010).…”

Section: Discussionmentioning

confidence: 97%

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Mendoza-Garcés

Mendoza-Rodríguez

Jiménez-Trejo

et al. 2011

The Anatomical Record

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In the hippocampus, estrogens increase dendritic arborization, longterm potentiation, neuroprotection, and participate in many functions related with learning, memory, and affective behaviors. The presence of both estrogen receptors alpha (ERa) and beta (ERb) isoforms has been described in the hippocampus where they play different physiological roles. The aim of this study was to investigate, by using both techniques immunohistochemistry and Western Blot, the expression pattern of ERa and ERb in the hippocampus of the rat along the estrous cycle. Western blot analysis was used to confirm the specificity of the antibodies used against ERa and ERb and its relative content in the hippocampus. Results from immunohistochemical studies indicate that ERb expression increased more than the ERa in CA1 and CA3 regions during all phases of the estrous cycle. ERb immunoreactivity was mainly located in the nucleus and predominantly expressed in CA1 during estrous and metestrus, and in CA3 during diestrus. ERa was more abundant during estrous in comparison to other phases of the cycle in CA1 region, while it was more abundant during metestrus in CA3. Interestingly, the immunolocalization of ERa subtype was both cytoplasmic and nuclear. The overall results indicate that there is a differential expression, cellular localization, and distribution of both ER subtypes in CA1 and CA3 regions, suggesting different roles for these two receptors in the hippocampus along the estrous cycle. Anat Rec, 294:1913Rec, 294: -1919Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 97%

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Mendoza-Garcés

Mendoza-Rodríguez

Jiménez-Trejo

et al. 2011

The Anatomical Record

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“…Two main neuronal populations involved in feeding behavior exist in the ARC: the neuronal cells that produce neuropeptide Y (NPY) and agouti-related peptide (AgRP), which are orexigenic peptides, and a-melanocyte stimulating hormone (a-MSH), which is an anorexigenic peptide [36][37][38].…”

Section: Arcuate Nucleus (Arc)mentioning

confidence: 99%

Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

Yoshimura

Uezono²,

Ueta

2015

J Physiol Sci

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Anorexia, a loss of appetite for food, can be caused by various physiological and pathophysiological conditions. In this review, firstly, clinical aspects of anorexia nervosa are summarized in brief. Secondly, hypothalamic neuropeptides responsible for feeding regulation in each hypothalamic nucleus are discussed. Finally, three different types of anorexigenic animal models; dehydration-induced anorexia, cisplatin-induced anorexia and cancer anorexia-cachexia, are introduced. In conclusion, hypothalamic neuropeptides may give us novel insight to understand and find effective therapeutics strategy essential for various kinds of anorexia.

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“…The role of MC receptors in the regulation of penile erection, has received increasing attention [21][22][23]. In female rats, a-MSH has been shown to facilitate or inhibit lordosis depending on the hormonal status of the animals [24][25][26][27][28][29][30][31]. Melanocortinergic neurons are found largely in the arcuate nucleus of the hypothalamus, and project widely throughout the hypothalamus and limbic system.…”

Section: Interaction Of Melanocortins With the Hypothalamic-limbic Sementioning

confidence: 99%

Bremelanotide: An Overview of Preclinical CNS Effects on Female Sexual Function

Pfaus

Giuliano

Gelez

2007

The Journal of Sexual Medicine

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Introduction Bremelanotide is an analogue of the naturally occurring peptide α-melanocyte-stimulating hormone (α-MSH). It stimulates erection in men and male rats, and is currently in clinical trials for the treatment of erectile dysfunction. Aim To review the effects of bremelanotide, an analogue of the naturally occurring peptide α-MSH, on the preclinical indices of sexual desire in female rats, and where in the brain these actions may occur. Main Outcome Measures Appetitive sexual behaviors, such as solicitations, hops and darts, and pacing, were assessed along with consummatory behaviors such as lordosis. The involvement of brain regions was assessed following direct administration to the region, by the stimulation of molecular markers of neural activation, and using microdialysis to examine extracellular fluid for different neurotransmitters. Methods Using a model that allows ovariectomized, hormone-primed female rats to control the timing of sexual encounters with males, we tested the ability of bremelanotide to increase appetitive (proceptive) and/or consummatory sexual behaviors. Results Bremelanotide dramatically and selectively increased measures of solicitation in female rats, without altering pacing or lordosis, following both peripheral (subcutaneous) administration or infusions directly into the lateral ventricles or medial preoptic area (mPOA), but not the ventromedial hypothalamus. The mPOA is critical for the display of appetitive sexual behaviors in females and males of a variety of species. Peripheral administration of bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior, and may work by activating dopamine terminals in the mPOA. Conclusions To the extent that solicitations indicate the desire of female rats to engage in sexual activity, bremelanotide appears to possess the behavioral, pharmacological, and neuroanatomical specificity required of a drug in the treatment of hypoactive sexual desire disorders.

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The inter-relationship between gonadal steroids and POMC peptides, β-endorphin and α-MSH, in the control of sexual behavior in the female rat

Cited by 26 publications

References 34 publications

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat

Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

Bremelanotide: An Overview of Preclinical CNS Effects on Female Sexual Function

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