The interaction among obesity, Type 2 diabetes mellitus, and periodontitis in Vietnamese patients

Pham, Thuy Anh Vu; Tran, Thao Thi Phuong

doi:10.1002/cre2.106

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…Our findings indicate that periodontal health was poor in obese diabetic group compared to the obese non-diabetic group. Similar results were reported by Pham and Tran in 2017 [ 16 ] in Vietnamese population, and Samira et al, in 2008 [ 17 ] in Iranian population.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of gingival and periodontal status in obese and non-obese type II diabetic patients – a cross sectional study

SriChinthu

Pavithra

Kumar

et al. 2020

Medicine and Pharmacy Reports

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Objective. The aim of this study was to evaluate gingival and periodontal status in obese and non-obese type II Diabetic Patients. Methods. The study population comprised of 75 subjects visiting the outpatient department of our institution, divided into three different groups, group 1 (obese diabetic), group 2 (non-obese diabetic), and group 3 (obese, non-diabetic). Diabetic status was assessed with HbA1c values and obesity status was assessed by body mass index (BMI) score greater than or equal to 30 kg/m2. Gingival and periodontal status were assessed using the Gingival Index (GI) and Community Periodontal Index (CPI) respectively. Results. The mean gingival index score in group 1, group 2, and group 3 were 1.58, 1.54, and 1.25, respectively. Gingival status was poor among obese and non-obese diabetic subjects [Groups 1 & 2] when compared with obese non-diabetic patients [Group – 3]. The periodontal status showed that periodontal pockets were increased in diabetic obese group (15.4%), followed by diabetic non obese (4.66%), and non-diabetic obese (2%) group respectively and loss of attachment was severe in diabetic obese group (60.7%), followed by diabetic non obese (45.9%) and non-diabetic obese (15.3%) respectively. Conclusion. Gingival and periodontal status was poor in the obese diabetic group compared to non-obese diabetic and obese non diabetic group. Hence, the risk of gingivitis and periodontitis in obese diabetic patients should be addressed earlier to prevent further complications and achieve a good oral health status.

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Section: Discussionsupporting

confidence: 90%

Evaluation of gingival and periodontal status in obese and non-obese type II diabetic patients – a cross sectional study

SriChinthu

Pavithra

Kumar

et al. 2020

Medicine and Pharmacy Reports

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“…In our study, PI and BOP (%) were significantly higher in the CP+DM group. This was consistent with Emrich et al and Pham et al who stated that the plaque index and BOP were higher among patients with periodontitis and diabetes mellitus when compared to healthy individuals [24][25]. The possible etiology could be due to the host-immune interaction that results in an inflammatory response that ends up with periodontal destruction.…”

Section: Discussionsupporting

confidence: 90%

Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Ruth

Mahendra

Kumar

et al. 2020

Cureus

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Background The aim of the present study was to assess and quantify cluster of differentiation 163 (CD163) protein levels and CD163 messenger RNA (mRNA) gene expression in subgingival plaque samples of generalized chronic periodontitis subjects with and without type II diabetes mellitus (DM). Materials and methods Eighty chronic periodontitis subjects were selected and divided into 40 systemically healthy, generalized chronic periodontitis subjects (Group I) and 40 generalized chronic periodontitis subjects diagnosed with type II diabetes mellitus (Group II). Age, body mass index (BMI), income, plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. CD163 protein and gene expressions were quantified and compared between the groups. Results The mean age, BMI, income, PI, BOP %, and CD163 protein and gene expression were higher in Group II (p< 0.05) as compared to Group I. In Group I, CD163 protein levels showed a negative correlation with respect to BMI and PI, and this was statistically significant. In Group II, all the periodontal parameters showed a positive correlation with CD163 protein levels. Overall, PI and BOP % were significantly correlated with CD163 protein levels. Both CD163 protein and gene expression showed a negative correlation with each other (p= 0.001). Conclusion The elevated protein levels of CD163 in the subgingival plaque samples of generalized chronic periodontitis individuals with type II diabetes mellitus signify the involvement of CD163 in the pathogenesis of both periodontitis and diabetes mellitus. CD163 can play a challenging role as a diagnostic, as well as a prognostic biomarker, in both these inflammatory diseases.

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“…A total of 7,262 participants were included in the eight investigations, which comprised one nationwide study 5 and seven cross-sectional studies. [9][10][11][12][13][14][15] Two studies were performed in Central Vietnam, 9,10 five studies in Southern Vietnam, [11][12][13][14][15] and one nationwide study in 14 provinces and cities, which in total represents 62 of the provinces over the whole country. 5 All of the research was carried out between 1999 and 2020.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of periodontal disease among Vietnamese adults: A systematic review and meta-analysis

Duc¹,

Chi²,

Phan³

et al. 2023

Dent. Med. Probl.

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To synthesize previous findings on the prevalence of periodontal disease (PD) in the adult Vietnamese population, a search for peer-reviewed literature was conducted using the MEDLINE, PubMed and Scopus databases through January 10, 2022. Two reviewers individually assessed abstracts and full-text articles to determine their suitability for inclusion. Only English articles were included if their results described the prevalence of PD among the Vietnamese. Among 900 potential studies, 8 cross-sectional studies with 7,262 adult participants qualified to be included. We found that overall the prevalence of PD was 64.9% (95% confidence interval (CI): 45-81%), with very high heterogeneity across the observed prevalence estimates (Q = 1,204.8776; df = 7; p < 0.001; I 2 = 99.42%). Further subgroup analyses stratified by age, location, sampling, study design, and region also revealed significant differences, with a higher prevalence of PD among (1) population-based studies, (2) participants aged ≥65 years, (3) participants with non-chronic diseases, (4) studies using the WHO, community periodontal index (CPI) and standard oral examinations, (5) studies conducted in Central Vietnam, and (6) studies using randomization sampling (p < 0.01) than in other populations. Sensitivity analyses validated the stability of the current findings. Within the limits of the available evidence, this meta-analysis showed a high percentage of Vietnamese adults suffer from PD. Nonetheless, the findings should be taken cautiously due to the limited number of published articles and the possibility of bias in the included research. More well-designed studies with larger sample sizes are thus required for further verification.

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The interaction among obesity, Type 2 diabetes mellitus, and periodontitis in Vietnamese patients

Cited by 10 publications

References 42 publications

Evaluation of gingival and periodontal status in obese and non-obese type II diabetic patients – a cross sectional study

Evaluation of gingival and periodontal status in obese and non-obese type II diabetic patients – a cross sectional study

Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Prevalence of periodontal disease among Vietnamese adults: A systematic review and meta-analysis

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