The interaction between homatropine and optical blur on choroidal thickness

Sander, Beata P.; Collins, Michael J.; Read, Scott A.

doi:10.1111/opo.12450

Cited by 22 publications

(27 citation statements)

References 51 publications

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“…administered 0.5 per cent atropine 22 hours prior to exposing subjects to −2.00 D hyperopic blur and found that prior atropine use negated the thinning effect of the hyperopic blur. Sander et al used two per cent homatropine in combination with ±3.00 D of blur and found that after 60 minutes, the homatropine had eliminated the thinning effect of minus blur, similar to the longer‐term findings of Chiang and Phillips . These findings suggest that a muscarinic pathway may be involved in the eye’s response to minus blur.…”

Section: Changes In the Choroid Associated With Environmental Factorsmentioning

confidence: 79%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.

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Section: Changes In the Choroid Associated With Environmental Factorsmentioning

confidence: 79%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

View full text Add to dashboard Cite

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Section: Discussionmentioning

confidence: 99%

“…Previous studies in human adults have measured short-term axial length changes in response to defocus after 30 minutes and 1 hour 20,21 . With myopic defocus, there were axial length reductions of 9 μm after 30 minutes and 13 μm after 60 minutes, and with hyperopic defocus there were axial length elongations of 5 to 9 μm after 30 minutes, and 8 to 11 μm after 60 minutes 20,21 . Our findings from the current study are consistent with these previous reports in young adults, with an average decrease of −7 µm with myopic defocus and an average increase of +9 µm with hyperopic defocus after 30 minutes which then peaked at ±10 µm of change after 60 minutes.…”

Section: Discussionmentioning

confidence: 99%

“…In human eyes, the response to short-term imposed defocus has also been investigated [17][18][19][20] . Exposing the eyes of children and young adults to short periods (1 or 2 hours) of monocular myopic and hyperopic defocus leads to small but statistically significant bi-directional changes in axial length (measured from the anterior cornea to the retinal pigment epithelium) and choroidal thickness 17,20,21 . In a recent study of presbyopic adults, significant bi-directional changes in choroidal thickness after 1 hour of imposed myopic and hyperopic defocus were also reported 22 .…”

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confidence: 99%

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The time course of the onset and recovery of axial length changes in response to imposed defocus

Delshad

Collins

Read

et al. 2020

Sci Rep

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In this study we investigated the time course of the axial length response to 60 minute episodes of continuous myopic and hyperopic defocus, testing the hypothesis that the human eye, similar to those of other animals 17,18 , would be able to detect and respond to defocus within minutes of exposure to blur. We further assessed the persistence of axial length changes following the cessation of myopic and hyperopic defocus, during a period of clear vision, hypothesizing that the response to myopic defocus would be more enduring than the response to hyperopic defocus. Given that the visual system is also known to compensate for optical defocus through a gradual improvement in defocused visual acuity (VA) over time (blur adaptation) 24-28 , we also examined the association between the time course of changes in defocused VA and axial length during exposure to myopic defocus.

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“…In contrast, changes in choroidal thickness after orthokeratology treatment remain equivocal, with various studies reporting either no significant changes during the first 9 months of lens wear,16 or an increase of approximately 20 μm in subjects wearing orthokeratology lenses for 3 weeks,17 6 months, and 1 year 18. However, some of these studies did not control for the influence of diurnal variation and performed measurements after cycloplegia, which is known to affect choroidal thickness and its response to defocus 19–21. To date, only two studies have analyzed the correlation between changes in axial length and choroidal thickness in subjects treated with orthokeratology.…”

Section: Introductionmentioning

confidence: 99%

Weekly Changes in Axial Length and Choroidal Thickness in Children During and Following Orthokeratology Treatment With Different Compression Factors

Lau

Wan

Cheung

et al. 2019

Trans. Vis. Sci. Tech.

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The interaction between homatropine and optical blur on choroidal thickness

Cited by 22 publications

References 51 publications

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Choroidal changes in human myopia: insights from optical coherence tomography imaging

The time course of the onset and recovery of axial length changes in response to imposed defocus

Weekly Changes in Axial Length and Choroidal Thickness in Children During and Following Orthokeratology Treatment With Different Compression Factors

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