The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

Hong, Liuzhi; Wen, Lutong; Niculescu, Michelle; Zhou, Fan; Zou, Yang; Shen, Guanghui; Wang, Wei; Liu, Yanlong; Chen, Yu‐Hsin; Wang, Fan; Chen, Li

doi:10.3389/fpsyt.2022.878960

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Consistent with previous studies (35,36), we found that anxiety and depression symptoms during withdrawal in AUD patients are highly correlated with alcohol dependence levels in withdrawal. There is an established relationship between alcohol and anxiety; high anxiety levels in AUD patients manifest during alcohol withdrawal (37-39).…”

Section: Discussionsupporting

confidence: 92%

The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders

Shen

Yang

et al. 2023

Front. Psychiatry

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ObjectiveAlcohol use disorder (AUD) is a common mental disorder characterized by repeated withdrawal episodes. Negative emotions during withdrawal are the primary factors affecting successful abstinence. Oxytocin is a critical modulator of emotions. OXTR, the oxytocin receptor, may also be a promising candidate for treating alcohol withdrawal symptoms. Previous studies indicated that people with different genotypes of OXTR rs2254298 were reported to suffer from more significant depressive or heightened anxiety symptoms when experiencing early adversity. The present study aims to explore the modulatory role of the polymorphism OXTR rs2254298 on mood disorders during alcohol withdrawal and to help researchers better understand and develop effective relapse prevention and interventions for alcohol use disorders.MethodsWe recruited 265 adult Chinese Han men with AUD. Anxiety and depressive symptoms were measured using the Self-Rating Anxiety Scale and Self-Rating Depression Scale. Alcohol dependence levels were measured using Michigan Alcoholism Screening Test. Genomic DNA extraction and genotyping from participants’ peripheral blood samples.ResultFirst, a multiple linear regression was used to set the alcohol dependence level, OXTR.rs2254298, interaction terms as the primary predictor variable, and depression or anxiety as an outcome; age and educational years were covariates. There was a significant interaction between OXTR rs2254298 and alcohol dependence level on anxiety (B = 0.23, 95% confidence interval [CI]: 0.01–0.45) but not on depression (B = −0.06, 95% CI: −0.30 – 0.18). The significance region test showed that alcohol-dependent men who are GG homozygous were more likely to experience anxiety symptoms than subjects with the A allele (A allele: β = 0.27, p < 0.001; GG homozygote: β = 0.50, p < 0.001). Finally, re-parameterized regression analysis demonstrated that this gene–environment interaction of OXTR rs2254298 and alcohol dependence on anxiety fits the weak differential susceptibility model (R2 = 0.17, F (5,259) = 13.46, p < 0.001).ConclusionThis study reveals a gene–environment interactive effect between OXTR rs2254298 and alcohol withdrawal on anxiety but not depression. From the perspective of gene–environment interactions, this interaction fits the differential susceptibility model; OXTR rs2254298 GG homozygote carriers are susceptible to the environment and are likely to experience anxiety symptoms of alcohol withdrawal.

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Section: Discussionsupporting

confidence: 92%

The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders

Shen

Yang

et al. 2023

Front. Psychiatry

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“…In addition, we re-analyzed the data to explain how alcohol use influences these results. As shown in Supplementary Table 1, MAST scores were positively correlated with SAS scores (r = 0.36, p < 0.001), suggesting that anxiety was positively correlated with alcohol dependence, as our previous study reported [36]. However, there is no significant correlation between polymorphisms of rs266729 and MAST scores (r = 0.003, p > 0.05).…”

Section: No Interactive Effect Of Alcohol Dependence and Adpn Rs26672...mentioning

confidence: 54%

Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility

Zhao¹,

Wu²,

Shen³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background and Aims: Nicotine dependence (ND)-induced anxiety might be modulated by genetic polymorphisms. The gene-byenvironment interaction can be fitted into the diathesis-stress and differential susceptibility models. Nevertheless, knowledge of the interaction between adiponectin (ADPN) polymorphisms and ND on the incident mental disorder is currently scarce. This study aims to understand the role of ADPN rs266729 on anxiety in patients with ND while elucidating the psychology model and the various reactions across genotypes. Methods: We included 315 Chinese males with confirmed ND, measured using the Fagerstrom test for nicotine dependence (FTND). Anxiety was assessed using the Self-rating Anxiety Scale. Genomic DNA was extracted and genotyped from peripheral blood. Hierarchical regression models were used to test the interactions. Results: There was a significant interaction between ADPN rs266729 and ND (β = -0.19, p < 0.05). The CC homozygote was more likely to be affected by ND-induced anxiety (β = 0.14, t = 4.43, p < 0.01). Re-parameterized regression models revealed that the interaction between ADPN rs266729 and ND could fit the strong differential susceptibility model (R 2 = 0.05, p < 0.001). Conclusions: ADPN rs266729 was correlated with susceptibility to anxiety symptoms among male adults with ND and could fit the differential susceptibility model. The CC homozygote of rs266729 was a plasticity factor that increased anxiety symptoms in individuals with ND.

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Modulating reward and aversion: Insights into addiction from the paraventricular nucleus

Huang,

Shi,

Tao

et al. 2024

CNS Neurosci Ther

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BackgroundDrug addiction, characterized by compulsive drug use and high relapse rates, arises from complex interactions between reward and aversion systems in the brain. The paraventricular nucleus (PVN), located in the anterior hypothalamus, serves as a neuroendocrine center and is a key component of the hypothalamic–pituitary–adrenal axis.ObjectiveThis review aimed to explore how the PVN impacts reward and aversion in drug addiction through stress responses and emotional regulation and to evaluate the potential of PVN as a therapeutic target for drug addiction.MethodsWe review the current literature, focusing on three main neuron types in the PVN—corticotropin‐releasing factor, oxytocin, and arginine vasopressin neurons—as well as other related neurons, to understand their roles in modulating addiction.ResultsExisting studies highlight the PVN as a key mediator in addiction, playing a dual role in reward and aversion systems. These findings are crucial for understanding addiction mechanisms and developing targeted therapies.ConclusionThe role of PVN in stress response and emotional regulation suggests its potential as a therapeutic target in drug addiction, offering new insights for addiction treatment.

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The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

Cited by 3 publications

References 46 publications

The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders

The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene–environment interaction in mood disorders

Adiponectin. rs266729 Polymorphism and Nicotine Dependence Interaction: Genetic Investigations on the Anxiety Susceptibility

Modulating reward and aversion: Insights into addiction from the paraventricular nucleus

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