The interaction between the swine infectious diseases agents and low levels of mycotoxins in swine feed

Radulović, Jasna Prodanov; Došen, Radoslav; Stojanov, İgor; Polaček, Vladimir; Baloš, Milica Živkov; Marčić, Doroteja; Pušić, Ivan

doi:10.2298/bah1403433p

Cited by 5 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In gilts exposed to various doses of ZEN over a period of 4 weeks, the mycotoxin caused mucosal inflammations as well as damage to the epithelium and mucosa, which is consistent with the results documenting ZEN’s negative influence on intestinal defense [ 42 ]. The results of in vivo studies demonstrated that both low and high doses of ZEN could contribute to intestinal inflammations [ 148 ] and allergies [ 49 ].…”

Section: Activity Of Zenmentioning

confidence: 99%

Activity of Zearalenone in the Porcine Intestinal Tract

Gajęcka

Zielonka

2016

Molecules

View full text Add to dashboard Cite

This study demonstrates that low doses (somewhat above the No Observed Adverse Effect Level, NOAEL) of the mycoestrogen zearalenone (ZEN) and its metabolites display multispecificity towards various biological targets in gilts. The observed responses in gilts were surprising. The presence of ZEN and zearalenols (ZELs) did not evoke a response in the porcine gastrointestinal tract, which was attributed to dietary tolerance. Lymphocyte proliferation was intensified in jejunal mesenteric lymph nodes, and lymphocyte counts increased in the jejunal epithelium with time of exposure. In the distal digestive tract, fecal bacterial counts decreased, the activity of fecal bacterial enzymes and lactic acid bacteria increased, and cecal water was characterized by higher genotoxicity. The accompanying hyperestrogenism led to changes in mRNA activity of selected enzymes (cytochrome P450, hydroxysteroid dehydrogenases, nitric oxide synthases) and receptors (estrogen and progesterone receptors), and it stimulated post-translational modifications which play an important role in non-genomic mechanisms of signal transmission. Hyperestrogenism influences the regulation of the host’s steroid hormones (estron, estradiol and progesteron), it affects the virulence of bacterial genes encoding bacterial hydroxysteroid dehydrogenases (HSDs), and it participates in detoxification processes by slowing down intestinal activity, provoking energy deficits and promoting antiporter activity at the level of enterocytes. In most cases, hyperestrogenism fulfils all of the above roles. The results of this study indicate that low doses of ZEN alleviate inflammatory processes in the digestive system, in particular in the proximal and distal intestinal tract, and increase body weight gains in gilts.

show abstract

Section: Activity Of Zenmentioning

confidence: 99%

Activity of Zearalenone in the Porcine Intestinal Tract

Gajęcka

Zielonka

2016

Molecules

View full text Add to dashboard Cite

show abstract

“…Asymptomatic carriers of the bacterium, either those having survived the acute form of the disease or those that were subclinically infected, are an important source of infection. The severity of disease can be signifi cantly infl uenced by differences in virulence potential of different isolates and stress factors, different co-infections with other pathogens, and extrinsic factors such as poor husbandry and insuffi cient biosecurity [28,31,35,49].…”

Section: Actinobacillus Pleuropneumoniae (App)mentioning

confidence: 99%

“…It needs to be stressed that latently infected pigs can be a permanent source of reinfection in a herd. The latent infection may be reactivated by stress (transport, mixing of pigs) or due to swine feed contamination with different mycotoxins [28,31].…”

Section: Aujeszky's Disease -Pseudorabies (Ad)mentioning

confidence: 99%

“…In Serbia, commercial pig farrow-to fi nish farm systems are characterized by the presence of various predisposing factors, which signifi cantly infl uence the occurrence of respiratory diseases [28][29][30]. Compared to multi-site production systems, in farrow-to fi nish swine farms more opportunities for pathogens, environment and management interactions exist [24,25,31].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Current Swine Respiratory Diseases Morphology in Intensive Swine Production in Serbia

et al. 2020

View full text Add to dashboard Cite

Swine respiratory diseases represent one of the most frequent health issues in pig production worldwide. Despite the great progress that has been made in the field of diagnostics, control and prophylaxis, respiratory diseases still remain the most challenging health problem in modern commercial pig production. The list of infectious agents that cause respiratory diseases in swine is extensive and includes both, bacterial and viral pathogens. In Serbia, more than fifteen years after the introduction of modern vaccines, the list of bacterial pathogens related to swine respiratory infections still include Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Haemophilus parasuis and Pasteurella multocida. On the other hand, most commonly involved viral pathogens are Porcine Reproductive and Respiratory Syndrome Virus, Swine influenza virus, Porcine circovirus type 2 and Pseudorabies virus. The morphological features of pneumonia where several agents are involved, depend on the predominant etiological agent. Expanding knowledge of the main pathogens associated with swine respiratory diseases and the effects of their interactions on the disease outcome is important for further investigations of lung diseases and implementation of control strategies in commercial pig populations in Serbia. This review discusses the latest findings on swine respiratory disease and current trends in Serbian pig production.

show abstract

“…A major problem associated with animal feed contaminated with mycotoxins is not acute disease, but rather the ingestion of low levels of toxins, which may cause an array of metabolic, physiologic and immunologic disturbances (Pro danov-Radulović et al 2014;Waśkiewicz et al 2014). Consumption of fungal toxins in swine as a species may decrease resistance to infectious diseases (Prodanov-Radulović et al 2011;Prodanov-Radulović et al 2014). Also, chronic exposure can lead to anorexia, reduced weight gain, as well as nutritional efficiency and neuroendocrine changes (Pestka, 2007;Prodanov-Radulović et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Impact of fusarium mycotoxins on swine health - field observations

Radulović

Stojanov

Baloš

et al. 2017

Zb Mat srp prir nauk

View full text Add to dashboard Cite

Mycotoxins are structurally diverse fungal metabolites that can contaminate a variety of dietary components consumed by animals and humans. The aim of this paper was to present the field observations of clinical and pathological consequences on swine health in the cases when Fusarium mycotoxins were detected in swine feed. The material for research included the samples from swine farms located in the region of Vojvodina, where health disorders resembling intestinal problems in different swine categories were detected. The applied research methods included: epidemiological and clinical evaluation, gross pathology examination, bacteriological tissue testing originating from diseased dead animals. The presence of deoxynivalenol (DON), T-2 toxin and zearalenone (ZEA) in thirteen complete swine feed mixtures were analyzed by enzyme-linked immunosorbent assay methods, using Ridascreen?FAST DON, Ridascreen?FAST T2, and Ridascreen?FAST Zearalenon test kits (R-Biopharm, Germany). By clinical and pathological examination, the lesions predominantly located in digestive tract were observed in different swine categories. The problem of persistent enteric infections in suckling piglets and alteration of growth performance were notified in weaners and fatteners. In adult categories, reduced feed consumption, sometimes distinct feed refusal and vomiting were observed. In all examined samples of complete feed mixtures for different swine categories the concentration of DON exceeded the maximum permitted levels, but also the presence of other Fusarium mycotoxins was detected. The obtained results indicate the existence of feed mixtures contamination with low levels of Fusarium mycotoxins and their possible positive interaction with etiological agents present in swine farms. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR31071]

show abstract

The interaction between the swine infectious diseases agents and low levels of mycotoxins in swine feed

Cited by 5 publications

References 15 publications

Activity of Zearalenone in the Porcine Intestinal Tract

Activity of Zearalenone in the Porcine Intestinal Tract

Current Swine Respiratory Diseases Morphology in Intensive Swine Production in Serbia

Impact of fusarium mycotoxins on swine health - field observations

Contact Info

Product

Resources

About