The interaction effect of ANKK1/DRD2 TaqIA and HTR2C Cys23Ser on approach motivation in schizophrenic patients and normals

Abstract

A MANCOVA with sex and age as covariates revealed the effect of the 'DRD2 x HTR2C x diagnosis' interaction on the BAS scores (p=0.033). The effect was significant for the Fun-Seeking and Drive scales. Among patients, the carriers of the DRD2 TT/CT x HTR2C GG/G genotype showed the highest scores on the both scales, and those with the minor alleles in the two loci had the lowest ones. Differences between these groups were nominally significant for both the Fun-Seeking and Drive, but did not survive the correction for multiple comparisons. Among controls, subjects without minor alleles demonstrated the highest scores on these two scales. They differed significantly from the carriers of the DRD2 TT/CT+HTR2C GG/G genotype on the Fun-Seeking (p=0.008). No effects of DRD2 and HTR2C on TEPS scores were found. In general, the results of the study can be interpreted in favor of the hypothesis about the role of the HTR2C and DRD2 genes interaction in the variability of the activational aspects of approach motivation in schizophrenia and healthy subjects. However, the lack of differences survived correction for multiple comparisons makes it difficult to interpret the revealed effects.

CLASH-VLT: a full dynamical reconstruction of the mass profile of Abell S1063 from 1 kpc out to the virial radius

“…To date, there are inconsistent results from several association studies of ANKK1 polymorphism with schizophrenia and its clinical phenotypes (Alfimova et al, 2017(Alfimova et al, , 2018Arab & Elhawary, 2015;Eisenstein et al, 2017;Nkam et al, 2017;Parsons et al, 2007;Ponce et al, 2009;Wishart et al, 2011;Yao, Pan, Ding, Pang, & Wang, 2015;Zhang et al, 2014). It has been hypothesized that rs1800497 polymorphism is likely to have a modifying effect rather than causative effect on schizophrenia (Zhang et al, 2014).…”