The Interferon-Induced Gene Isg12 Is Regulated by Various Cytokines as the Gene 6-16 in Human Cell Lines

Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells

“…IFNs have been shown to regulate the expression of the IFI 6-16 gene (Gjermandsen et al, 2000). Specifically, IRF-1 expression induces transcription of IFI 6-16 (Henderson et al, 1997).…”

Avian influenza virus infection induces differential expression of genes in chicken kidney

“…The ISG12 gene belongs to a family of small, interferon alpha (IFNa) inducible genes with unknown function (Gjermandsen et al, 2000). A recent study showed that neuronal ISG12 gene expression is associated with resistance to Sindbis virus-induced encephalitis and its expression significantly delays Sindbis virus-induced death in neonatal mice (Labrada et al, 2002).…”

Identification of ISG12b as a Putative Interferon-inducible Adipocytokine which is Highly Expressed in White Adipose Tissue

“…The expression of ISG12b has been shown to be induced by interferon-(IFN ) in a number of cell lines including HeLa, MCF7, and HFL1 14,15) . However, the function of ISG12b has not been sufficiently elucidated.…”

“…We cloned the cDNA of interferon-stimulated gene 12b (ISG12b) through such a screening. ISG12b was originally identified in human breast carcinoma cells 14) , and its expression has been shown to be induced by interferon 15,16) , which is a cytokine involved in the control of various inflammatory and anti-inflammatory responses. Investigation of the expression of ISG12b in adipose tissue suggests that ISG12b is an interferon-regulated adipocytokine involved in inflammation, and possibly also in the development of metabolic disorders and various vascular complications.…”