The interplay between inflammation and thrombosis in COVID-19: Mechanisms, therapeutic strategies, and challenges

Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis

“…FXII has biological activity in various cells, such as endotheliocytes, platelets, and monocytes, which determines its diverse role in physiological and pathological processes. 12,13 This study aims to investigate the relationship between inflammatory markers and coagulation activity in the setting of AF, including the impact of this interaction on clinical presentation and outcome in patients with AF.…”

“…FXII has biological activity in various cells, such as endotheliocytes, platelets, and monocytes, which determines its diverse role in physiological and pathological processes. 12 , 13 …”

Table3.XLSX

“…Controlled inflammation is beneficial as it helps remove irritants, damaged cells, and pathogens (Nakkala et al, 2021). However, dysregulated uncontrolled inflammation can cause several chronic diseases, even death (Ma and Willey, 2022). Glucocorticoids, broad-spectrum anti-inflammatory agents, are used to treat inflammatory diseases but are associated with several adverse effects, including high blood pressure, hyperglycemia, and adrenal insufficiency (Sun et al, 2022).…”

Table5.XLSX

“…Controlled inflammation is beneficial as it helps remove irritants, damaged cells, and pathogens (Nakkala et al, 2021). However, dysregulated uncontrolled inflammation can cause several chronic diseases, even death (Ma and Willey, 2022). Glucocorticoids, broad-spectrum anti-inflammatory agents, are used to treat inflammatory diseases but are associated with several adverse effects, including high blood pressure, hyperglycemia, and adrenal insufficiency (Sun et al, 2022).…”