The intra-myocardial distance function used in inverse computations of the timing of depolarization and repolarization

Abstract

Abstract

Application of the fastest route algorithm in the interactive simulation of the effect of local ischemia on the ECG

“…a (Geometry A) as computed using a reaction-diffusion model [10]. b (Geometry B) results of a dedicated inverse procedure [29]. The sites at which depolarization was initiated are marked (arrows pointing to the white dots, not all white dots are visible).…”

“…In this application, the FRA uses elements s i,j for all node pairs that can be connected by a straight line segment in 3D space passing entirely through myocardial tissue [29].…”

“…The triangulated geometry of the surface S h bounding the myocardium was specified by 1,500 vertices. The timing of depolarization at these nodes was estimated by means of a dedicated inverse procedure [29]. The corresponding isochrones are shown in Fig.…”

“…finding the shortest route between any two locations. This algorithm has previously been applied to generate activation sequences of the heart while assuming uniform propagation velocity [29]. In the current application of the algorithm, locally different propagation velocities are considered, and the timing of activation is found by computing the time traveled along the fastest route between any two locations.…”

“…It includes the description of the FRA per se, and its performance based on two activation sequences. The first one was obtained from an diffusion-reaction model, the second one from a dedicated inverse procedure [29].…”