The inulin hydrogen breath test accurately reflects orocaecal transit time

Schneider, A; Jepp, K.; Murczynski, L.; Biniek, U.; Stein, Jürgen M.

doi:10.1111/j.1365-2362.2007.01862.x

Cited by 20 publications

(17 citation statements)

References 24 publications

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“…However, there was also a moderate rise in GLP-1 following cellulose supplementation, though not significant, and it may be the case that cellulose may be fermentable over time [25] or in certain individuals [26] . The increase in GLP-1 occurred 2-3 h before the inulin would have reached the colon to undergo fermentation [27] . Therefore, it is possible that the GLP-1 rise we observed reflects a longer-term adaptive process, which enhances the capacity of the L cell to secrete GLP-1 [28,29] .…”

Section: Discussionmentioning

confidence: 99%

A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes

Guess¹,

Dornhorst²,

Oliver³

et al. 2015

Ann Nutr Metab

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Background: Fermentable carbohydrates (FCHO) have been shown to improve insulin sensitivity in normoglycaemic and insulin-resistant subjects. However, there are no data on subjects with prediabetes. We aimed to investigate the effect of the FCHO inulin, on glucose homeostasis in subjects with prediabetes. Methods: In a double-blind and placebo-controlled crossover study, 40 volunteers with prediabetes were randomly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial, following a 4-week dose-escalation run-in. Fasting insulin and glucose were measured for all subjects. Fifteen of the 40 subjects also underwent a meal tolerance test to assess insulin sensitivity, free fatty acids and glucagon-like peptide-1 concentrations. A subanalysis was carried out to examine any differences between the prediabetes subtypes. Results: Inulin was associated with a significant increase in _{(0-30 min)}incremental AUC (iAUC) for insulin (treatment: p < 0.04) and _{(0-60 min)}iAUC for insulin (treatment: p < 0.04) compared to control. There was a significant reduction in insulin resistance measured by the homeostatic model assessment in the isolated-impaired fasting glucose (p < 0.05) but not in the isolated-impaired glucose tolerance groups (p = 0.59). Conclusion: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to people at risk of diabetes, which warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes

Guess¹,

Dornhorst²,

Oliver³

et al. 2015

Ann Nutr Metab

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show abstract

“…5 g of inulin does not affect the gastric or intestinal motility [23,24]. A cutoff >10 ppm indicates that the substrate has reached the colon.…”

Section: Inulin Hydrogen Breath Testmentioning

confidence: 99%

Methods and functions: Breath tests

Braden

2009

Best Practice & Research Clinical Gastroenterology

101

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“…There were also no significant differences in orocecal transit time with 5 g and 10 g inulin. In a study of 29 subjects, Schneider et al found a median orocecal transit time of 300 minutes (range 180-420 minutes) for a liquid nutrient test meal containing 5 g of inulin (37). Correlation between the inulin-based test and the lactose 13 C-ureide test was moderate [r=0.85 (37) and r=0.72].…”

Section: Evaluation Of Small Bowel Transitmentioning

confidence: 99%

“…The pitfalls of the inulin based test include the finding that 7-10% of subjects were hydrogen non-producers in response to 5 g of inulin (36,37), and one of the studies showed that the median orocecal transit time was about 30 minutes shorter with inulin than with the lactose 13 C-ureide test (37), suggesting the possibility that inulin may also accelerate orocecal transit time. At present, inulin based hydrogen breath tests have not demonstrated responsiveness to pharmacological manipulation of transit and have not been applied in disease states affecting motility.…”

Section: Evaluation Of Small Bowel Transitmentioning

confidence: 99%