The involvement of liquid crystals in multichannel implanted neurostimulators, hearing and ENT infections, and cancers

Ch, Chouard; Binot, Christiane; Sadoc, Jean‐François

doi:10.1080/00016489.2018.1554265

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Implantable medical electronic devices (IME) such as artificial retinas, 1–3 cardiac pacemakers 4,5 and neurostimulators 6–8 play a huge role in keeping human physiological functions stable and facilitating disease treatment. 9 The ability of electronic devices to work stably in the human body for a long time requires a safe, stable and uninterrupted power supply to provide continuous power.…”

Section: Introductionmentioning

confidence: 99%

Flexible lead-free cruciform piezo-arrays for implantable wireless energy harvesting on complex surfaces

Zhu,

Xue,

Zhou

et al. 2024

J. Mater. Chem. A

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Section: Introductionmentioning

confidence: 99%

Flexible lead-free cruciform piezo-arrays for implantable wireless energy harvesting on complex surfaces

Zhu,

Xue,

Zhou

et al. 2024

J. Mater. Chem. A

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“…Advancements in implantable medical electronics (IMEs), such as cardiac pacemakers, 1,2 cochlear implant, 3,4 and neurostimulators, 5,6 offer many benefits in terms of monitoring and mapping biological signals, supporting and enhancing physiological functions, and mitigating and treating diseases. 7 To maintain their continuous operation, current IMEs that operate at powers ranging from several microwatts to a few hundred microwatts are typically powered by implanted batteries.…”

Section: Introductionmentioning

confidence: 99%

Flexible lead-free piezoelectric arrays for high-efficiency wireless ultrasonic energy transfer and communication

Jiang

Wei

et al. 2022

Mater. Horiz.

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Effect and Mechanism of the Lenvatinib@H-MnO2-FA Drug Delivery System in Targeting Intrahepatic Cholangiocarcinoma

Ning

Yang

Yan

et al. 2022

CPD

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Background: To investigate the effects of the Lenvatinib@H-MnO2-FA administration system on the proliferation and apoptosis of Intrahepatic cholangiocarcinoma (ICC) and the underlying molecular mechanism. Materials and Methods: In this research, hollow MnO2 (H-MnO2) was synthesized via the modified Stöber method, and H-MnO2 was modified with polyethylene glycol-bis (Amine) (NH2-PEG-NH2) and folic acid (FA) to obtain H-MnO2-PEG-FA (H-MnO2-FA). Lenvatinib was coated in the hollow cavity of H-MnO2-PEG-FA to further form a nanometre drug-carrying system (lenvatinib@H-MnO2-PEG-FA). Lenvatinib@H-MnO2-FA was characterized through transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FT-IR) was used to verify that Lenvatinib was loaded on nanoparticles. Functionally, confocal laser scanning microscopy (CLSM), 2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were performed to determine the effect of lenvatinib@H-MnO2-FA on the proliferation and apoptosis of ICC cells (9810 cells). Finally, the protein levels of Raf-1MEK1/2-ERK1/2 signalling pathway components were detected through Western blotting analysis.v Results: We successfully synthesised a Lenvatinib@H-MnO2-PEG-FA administration system. The resulting nanomaterials had excellent biological stability and improved targeting effects. Functionally, lenvatinib@H-MnO2-FA inhibited the proliferation of 9810 cells. The Bcl-2 protein level was significantly downregulated, and the caspase-3 protein level was significantly upregulated, indicating that lenvatinib@H-MnO2-PEG-FA promoted the apoptosis of 9810 cells. Mechanistically, Lenvatinib@H-MnO2-FA increased the phosphorylation levels of Raf, MEK1/2 and ERK1/2. Conclusions: H-MnO2-FA can more effectively deliver Lenvatinib to inhibit proliferation and promote apoptosis in ICC, could be the promising drug delivery nano-vehicles for delivery drugs.

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The involvement of liquid crystals in multichannel implanted neurostimulators, hearing and ENT infections, and cancers

Cited by 3 publications

References 57 publications

Flexible lead-free cruciform piezo-arrays for implantable wireless energy harvesting on complex surfaces

Flexible lead-free cruciform piezo-arrays for implantable wireless energy harvesting on complex surfaces

Flexible lead-free piezoelectric arrays for high-efficiency wireless ultrasonic energy transfer and communication

Effect and Mechanism of the Lenvatinib@H-MnO2-FA Drug Delivery System in Targeting Intrahepatic Cholangiocarcinoma

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