This article introduces the Comprehensive Efficiency Index (CEI) as a tool for assessing and improving hospital performance across various domains. The CEI offers a holistic approach by integrating indicators of productivity, quality of care, economic efficiency, and patient satisfaction. Through targeted analysis and strategic interventions guided by the CEI, hospitals can optimize resource utilization, enhance patient outcomes, and deliver high-quality care. Additionally, the integration of clinical governance principles ensures alignment with clinical standards and patient safety, while project management methodologies facilitate efficient implementation of improvement initiatives. Moreover, risk management practices are essential in identifying and mitigating potential threats to hospital operations and patient care quality. By incorporating risk management strategies, hospitals can proactively address challenges and enhance organizational resilience. By incorporating clinical governance, project management, and risk management principles, hospitals can achieve comprehensive performance enhancement and sustainable efficiency gains.