The Kidney in Scleroderma

Oliver, Juan A.; Cannon, Paul J.

doi:10.1159/000180805

Cited by 42 publications

(7 citation statements)

References 11 publications

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“…Other studies have shown that renal crisis affects 7-18% of SSc patients, largely those with diffuse skin involvement and then, usually within the first 5-6 years of SSc onset (1,3,5,7,25). Renal crisis occurred in only 2 of our patients (4%), both of whom had diffuse SSc: for 6 years in one and for 11 years in the other.…”

Section: Discussionmentioning

confidence: 49%

Abnormalities of Renal Physiology in Systemic Sclerosis

Clements

Lachenbruch

Fürst

et al. 1994

Arthritis & Rheumatism

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Objective. To evaluate the prognostic value of measurements of renal plasma flow and circulating vasoactive hormones in patients with systemic sclerosis (SSc).Methods. Renal plasma flow (para-aminohippurate [PAH] clearance) and levels of selected circulating hormones (plasma renin activity [PRA] and serum aldosterone and catecholamines) were assessed in 57 SSc patients under the following conditions: at rest, in response to cold, while in upright position, and in response to sodium depletion. Survival was assessed 10.7 years after testing (20 patients had died).Results. Both unstimulated and stimulated PRA clearance rates were frequently elevated. Resting PAH clearances were usually abnormally low. PAH clearances and levels of aldosterone and catecholamines did not change during cold stimulation. Supine PRA levels

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Section: Discussionmentioning

confidence: 49%

Abnormalities of Renal Physiology in Systemic Sclerosis

Clements

Lachenbruch

Fürst

et al. 1994

Arthritis & Rheumatism

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“…All 3 survivors of scleroderma renal crisis required bilateral nephrectomy for control of hypertension. Only two of these patients survived for more than 1 year: one on dialysis and one with a transplant (12).…”

Section: Discussionmentioning

confidence: 99%

Variable response to oral angiotensin‐converting‐enzyme blockade in hypertensive scleroderma patients

Whitman

Case

Laragh

et al. 1982

Arthritis & Rheumatism

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Twelve scleroderma patients with hypertension, seven of whom had malignant hypertension and renal failure or scleroderma renal crisis, were treated with captopril. The first dose lowered mean pressure in all patients by 21.3 mmHg; in 6 patients it relieved encephalopathy . Blood pressure was controlled in all patients.Two of 7 patients with scleroderma renal crisis had improvement in renal function; the 5 patients who did not have malignant hypertension improved or stabilized. Despite good pressure control, however, renal failure developed in 5 patients with scleroderma renal crisis. The data indicated that captopril is effective antihypertensive therapy in scleroderma and, when given early, may prevent renal failure and death.Scleroderma is a disease in which deposition of collagen in skin and visceral organs is associated with

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“…Renal involvement is common in PSS and oliguric acute renal failure is the leading cause of death in this disease [5,7,8], Studies from this labora tory have shown marked depressions of renal cortical blood flow in PSS patients with renal failure [5], Reduced renal blood flow has also been documented in PSS patients in the absence of renal failure and hypertension under basal conditions [6] and during induction of Raynaud's phenomenon [5]. This latter observation suggests that there is a functional abnormality in the regulation of renal blood flow (in addition to the renal vascular lesions) in PSS.…”

Section: Progressive Systemic Sclerosis (Pss) Is a Disease Of Unknownmentioning

confidence: 99%

Renal Vasoactive Hormones in Scleroderma (Progressive Systemic Sclerosis)

Oliver¹,

Vinci²,

Bowden³

et al. 1981

Nephron

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Plasma renin activity and the urinary excretions of kallikrein, kinin, immunoreactive PGE (iPGE) and aldosterone were determined in 23 patients with progressive systemic sclerosis (PSS) on a fixed sodium and potassium intake who had no clinically apparent renal disease. Urinary excretions of kallikrein and kinin in the PSS patients were not significantly different from those of a group of sex and race-matched normal controls. In the female PSS patients urinary excretion of iPGE was also found to be normal. Upright PRA was appropriate for the urinary sodium excretion in 18 PSS patients (13 normotensive and 5 hypertensives) but was significantly elevated in the remaining 5 (all normotensive). The data suggest that the renal kallikrein-kinin and prostaglandin systems are unaltered in PSS patients without clinical evidence of renal disease.

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The Kidney in Scleroderma

Cited by 42 publications

References 11 publications

Abnormalities of Renal Physiology in Systemic Sclerosis

Abnormalities of Renal Physiology in Systemic Sclerosis

Variable response to oral angiotensin‐converting‐enzyme blockade in hypertensive scleroderma patients

Renal Vasoactive Hormones in Scleroderma (Progressive Systemic Sclerosis)

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