The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution

Rawashdeh, Abdel‐Monem M.; Mizyed, Shehadeh; Mahmoud, Sabri S.; Marji, Deeb

doi:10.1016/j.saa.2007.12.046

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Because of the facile photodegradation of tenoxicam in solution23 and the potential to modify this behavior by complexation,80 solid‐state photodegradation studies were also performed to determine if the SDDs produced in this study showed any potential liability from enhanced photodegradation relative to Form III. As previously discussed, the SDDs exhibited a yellow color that was lighter than that of tenoxicam Form III.…”

Section: Resultsmentioning

confidence: 99%

The genes that underlie fatty liver disease: The harvest has begun #

Weiskirchen

Wasmuth

2009

Hepatology

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Section: Resultsmentioning

confidence: 99%

The genes that underlie fatty liver disease: The harvest has begun #

Weiskirchen

Wasmuth

2009

Hepatology

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“…Considering the size of a-, band g-CDs, a has the smallest cavity (4.7 Å) which may be unable to include the lornoxicam molecule with the cavity, while band g-CDs have larger cavities that enables them to include the LXM inside their cavities. 34,35 The stability constants for different OXM derivatives with b-CDs (III-V), assuming a 1 : 1 stoichiometry are listed in Table 1. Phase solubility experiments at 25 C showed an increase of the drug solubility in a linear form as a function of CDs concentration indicating formation of a soluble complex of the A L type.…”

Section: Characterization Of Lxm/b-cds Inclusion Complexesmentioning

confidence: 99%

Novel screen printed potentiometric sensors for the determination of oxicams

et al. 2015

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The construction and performance characteristics of new sensitive and selective sensors based on functionalized multi-walled carbon nanotubes/b-cyclodextrin nanocomposite (FMWCNTs/b-CD) was demonstrated for potentiometric determination of different anti-inflammatory agents including lornoxicam, meloxicam, piroxicam and tenoxicam. Screen printed sensors (SPEs) modified with FMWCNTs/b-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-PNPE) showed proper electroanalytical performances with a Nernstian compliance range between 61.2 and 52.6 mV decade À1 activity and a detection limit of 6.0 Â 10 À7 mol L À1 for different oxicam derivatives. Modification with carbon nanotube composite as sensing material remarkably improved the potential stability and lifetime of the fabricated sensors. The proposed sensors offer a simple analytical tool for determination of different oxicam derivatives in their pharmaceutical formulations under batch and flow injection analysis (FIA) conditions.

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“…The assessment of the spectrophotometry constants was done using the SQUAD data processing software [11]. It is important to mention that Rawashdeh et al [12] studied the effect of cyclodextrins on photodegradation of Tenox at pH 4, 7 and 10. They reported that after 60 min of Tenox irradiation with UV light, its photodegradation was extensive.…”

Section: Spectrophotometry Uv-vis Studymentioning

confidence: 99%