The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Sassa, Yukio; Ishikawa, Keijiro; Asato, Ryo; Ishibashi, Tatsuro; Kono, Toshihiro

doi:10.1038/eye.2016.20

Cited by 11 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They revealed that the MCP‐1 levels had a tendency to instantly rise subsequent to surgery and then decline with time. This study also showed that in case of a second tractional retinal detachment operation, the levels of MCP‐1 were considerably higher than those with other retinal disorders; including pars plana vitrectomy, neovascular glaucoma, macular pucker, and secondary intraocular lens implant (Sassa et al 2016).…”

Section: Mcp‐1 In Drmentioning

confidence: 62%

Monocyte chemoattractant protein-1 (MCP-1/CCL2) in diabetic retinopathy: latest evidence and clinical considerations

Taghavi

Hassanshahi

Kounis

et al. 2019

J. Cell Commun. Signal.

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is considered as a diabetes-related complication that can render severe visual impairments and is also a risk factor for acquired blindness in both developed as well as developing countries. Through fibrovascular epiretinal membranes (ERMs), this condition can similarly lead to tractional retinal detachment. Laboratory efforts evaluating the DR pathogenesis can be provided by ocular vitreous fluid and ERMs resulting from vitrectomy. The clinical stages of DR are significantly associated with expression levels of certain chemokines, including monocyte chemotactic protein-1 (MCP-1) in the intraocular fluid. The MCP-1 is also a known potent chemotactic factor for monocytes and macrophages that can stimulate them to produce superoxide and other mediators. Following hyperglycemia, retinal pigmented epithelial (RPE) cells, endothelial cells, and Müller's glial cells are of utmost importance for MCP-1 production, and vitreous MCP-1 levels rise in patients with DR. Increased expression of the MCP-1 in the eyes can also play a significant role in the pathogenesis of DR. In this review, current clinical and laboratory progress achieved on the MCP-1 and the DR concerning neovascularization and inflammatory responses in vitreous and/or aqueous humor of DR patients was summarized. It was suggested that further exploration of the MCP-1/CCR2 axis association between clinical stages of DR and expression levels of inflammatory and angiogenic cytokines and chemokines, principally the MCP-1 might lead to potential therapies aiming at neutralizing antibodies and viral vectors.

show abstract

Section: Mcp‐1 In Drmentioning

confidence: 62%

Monocyte chemoattractant protein-1 (MCP-1/CCL2) in diabetic retinopathy: latest evidence and clinical considerations

Taghavi

Hassanshahi

Kounis

et al. 2019

J. Cell Commun. Signal.

View full text Add to dashboard Cite

show abstract

“…Yoshida et al [ 7 ] had reported the association between MCP-1 and diabetic macular edema after PPV. There’s also evidence that the MCP-1 concentration was markedly elevated after PPV, implying an association between the prolonged inflammation after vitrectomy and complications, especially TRD [ 20 ]. We suppose that the inflammatory reaction induced by high MCP-1 might aggravate macular edema or progression of PDR, which could compromise postsurgical visual function.…”

Section: Discussionmentioning

confidence: 99%

Aqueous humor monocyte chemoattractant protein-1 predicted long-term visual outcome of proliferative diabetic retinopathy undergone intravitreal injection of bevacizumab and vitrectomy

Lei

Ding²,

Xie

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

Purpose We aim to investigate the risk factors associated with the prognosis of proliferative diabetic retinopathy (PDR) after a sequential treatment of intravitreal injection of bevacizumab (IVB) and pars plana vitrectomy (PPV). Methods In this cohort study, 63 eyes from 55 patients (21 females) diagnosed with PDR, who needed PPV for non-clearing vitreous hemorrhage or fibrovascular membrane proliferation were enrolled. All the eyes underwent IVB followed by PPV. Anterior chamber tap was performed at the beginning of both procedures to evaluate the concentration of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-8, and monocyte chemoattractant protein (MCP)-1. Results Forty-seven patients (54 eyes) were followed over six months, averaging 12±5 (6–19) months. The concentration of VEGF significantly decreased after IVB (P<0.001), while other cytokines did not change significantly. The aqueous humor level of IL-8 after IVB (R = 0.378, P = 0.033), MCP-1 before (R = 0.368, P = 0.021) and after (R = 0.368, P = 0.038) IVB, and combined phacoemulsification (R = 0.293, P = 0.032) was correlated with the logMAR visual acuity at the last follow-up. Multivariate analysis showed that MCP-1 was the predictor for a worse visual outcome (B = 0.108, 95% CI 0.013–0.202; P = 0.027). Conclusions MCP-1 was a predictor for the unfavorable visual outcome of PDR after IVB pretreatment and PPV.

show abstract

“…Cytokine levels in VF at the time of primary vitrectomy surgeries might vary depending on the severity of diseases and timing of the surgeries. For instance, in cases with PDR, histories of anti-VEGF treatment, or laser photocoagulation might affect the results 9–11…”

Section: Discussionmentioning

confidence: 99%

Biological Characteristics of Subsilicone Oil Fluid and Differences With Other Ocular Humors

Shimizu

Kaneko

Suzumura

et al. 2019

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose: Subsilicone oil fluid (SOF) in eyes with silicone oil (SO) endotamponade possibly has a role in complications (e.g., vision loss); thus, we aimed to examine inflammatory cytokine and electrolyte levels and retinal glial cell viability in SOF. Methods:We measured major inflammatory cytokine levels and electrolytes in SOF and compared them with those in vitreous fluid (VF) and anterior chamber fluid (ACF). We analyzed the correlation between inflammatory cytokines and retinal thickness in SO-filled eyes. Further, we measured the MIO-M1 cell viability in medium with SOF and compared it with that containing VF.Results: We collected and examined 57 SOF, 22 ACF, and 21 VF samples from eyes with PVR, PDR, RD, and MH. Interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 levels in SOF were significantly higher than those in ACF. There was no significant difference for all cytokines between SOF and VF. Retinal thickness changes during SO endotamponade were not correlated with the presence of any inflammatory cytokines. Levels of ferrous iron, but not of potassium, showed a significant decrease in SOF compared with VF. The WST-1 assay showed that SOFadded medium induced higher MIO-M1 cell viability than VF-added medium. Conclusions:We found no significant correlation between the change in the retinal thickness and cytokine levels, but SOF contains higher concentrations of cytokines and lower concentrations of ferrous iron and can be biologically distinguished from ACF and VF.Translational Relevance: Novel knowledge of inflammatory cytokine levels and electrolytes in SOF provides better understanding of pathology of SO-filled eyes.

show abstract

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Cited by 11 publications

References 24 publications

Monocyte chemoattractant protein-1 (MCP-1/CCL2) in diabetic retinopathy: latest evidence and clinical considerations

Monocyte chemoattractant protein-1 (MCP-1/CCL2) in diabetic retinopathy: latest evidence and clinical considerations

Aqueous humor monocyte chemoattractant protein-1 predicted long-term visual outcome of proliferative diabetic retinopathy undergone intravitreal injection of bevacizumab and vitrectomy

Biological Characteristics of Subsilicone Oil Fluid and Differences With Other Ocular Humors

Contact Info

Product

Resources

About