The L-shape relationship between hemoglobin, albumin, lymphocyte, platelet score and the risk of diabetic retinopathy in the US population

Ding, Ranran; Zeng, Yusong; Wei, Zhimei; He, Zitong; Jiang, Zhixin; Yu, Jinguo; You, Caiyun

doi:10.3389/fendo.2024.1356929

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Moreover, HALP has also been reported to be associated with the incidence of non-neoplastic diseases. Ding et al evinced that a lower HALP (≤ 42.9) value was an independent risk factor for diabetic retinopathy 11 . However, to data, studies analyzing the correlation between HALP scores and ED risk are limited.…”

Section: Introductionmentioning

confidence: 99%

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Chen,

Zhou

et al. 2024

Sci Rep

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Erectile dysfunction (ED) is related to nutritional and inflammatory factors. The hemoglobin, albumin, lymphocyte, and platelet score (HALP), a new index reflecting the nutritional and inflammatory status, has been associated with a higher risk of diabetic retinopathy, particularly at lower values (≤ 42.9). However, studies focusing on the relationship between HALP and ED risk are scarce. Hence, this study aimed to investigate the association between HALP and ED. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. Based on self-reported data, participants were classified into either the ED group or the non-ED group. Next, the HALP score was categorized into four quartiles (Q1–4). Weighted multivariate regression analysis was performed to assess the relationship between categorical HALP and ED risk. Additionally, restricted cubic spline (RCS) analysis was conducted to examine the association between continuous HALP scores and ED risk. Furthermore, subgroup analyses were conducted to examine the association between categorical HALP and the risk of ED based on age, as well as the status of hypertension, diabetes and cardiovascular disease. Finally, a mediation analysis was carried out to investigate the mediating effect of HALP and related parameters on the association between urinary cobalt levels and ED. Initially, the data of 21,161 participants were collected. After implementing the inclusion and exclusion criteria, 3406 participants were included in the final analyses. Weighted multivariate regression analysis demonstrated that the Q4 HALP group was associated with a lower risk of ED (OR 0.96, 95% confidence intervals 0.92–1.00, P = 0.037). Meanwhile, RCS analysis showed that HALP was nonlinearly associated with the risk of ED. In addition, subgroup analyses demonstrated that participants in the Q3/4 HALP group had a significantly lower ED risk than those in the Q1 group among patients aged ≥ 50 years, as well as those with hypertension and diabetes. Lastly, mediation analysis revealed that HALP and its associated parameters had a marginal average causal mediation effect on the relationship between urinary cobalt levels and ED risk (P > 0.05). In US adults, high HALP scores were correlated with a lower risk of ED. The relationship was more pronounced in participants aged ≥ 50 years with hypertension and diabetes. Furthermore, HALP and its parameters may not mediate the association between urinary cobalt levels and ED risk.

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Section: Introductionmentioning

confidence: 99%

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Chen,

Zhou

et al. 2024

Sci Rep

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Hemoglobin, albumin, lymphocyte, and platelet (HALP) score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes

Xing,

Xie,

Zhong

et al. 2024

Preprint

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Background The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been identified as a potential prognostic marker in various conditions. However, its relationship with the incidence and mortality of diabetic kidney disease (DKD) in type 2 diabetes patients remains unexplored. This study aims to explore the relationship between the HALP score and both the incidence and mortality of DKD in type 2 diabetes, as well as whether reversing the HALP score could reduce mortality outcomes. Methods This study included 25,750 type 2 diabetes patients from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) and Southwest China (2013–2022). HALP score was calculated as [hemoglobin (g/L) × albumin (g/L)×lymphocytes (/L)]/platelets (/L). DKD was diagnosed based on urine albumin to creatinine ratio (ACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m². The relationship between HALP score and DKD was explored using logistic regression model, and Cox regression models were used to evaluate its association with all-cause and cause-specific mortality. Subgroup analyses explored the effects of dietary fiber intake and NSAIDs use on HALP score and mortality. Results Higher HALP score were significantly associated with a lower risk of DKD (NHANES, HR 0.502; Southwest China, HR 0.528) in an antagonist manner. Additionally, higher HALP score was related to decreased all-cause (HR 0.765, p < 0.001) and cardiovascular disease(CVD)-related mortality(HR 0.667, p < 0.001).We also discovered the same outcome in DKD patients with low dietary fiber intake (HR 0.695, p < 0.001) or NSAIDs use (HR 0.733, p < 0.001). The magnitude of associations was not materially altered in any of the sensitivity analyses. Conclusions High HALP score was independently associated with risk of DKD and its all-cause and cardiovascular mortality. Regular HALP monitoring could aid in risk stratification and clinical decisions for DKD in type 2 diabetes.

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The L-shape relationship between hemoglobin, albumin, lymphocyte, platelet score and the risk of diabetic retinopathy in the US population

Cited by 2 publications

References 40 publications

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study

Hemoglobin, albumin, lymphocyte, and platelet (HALP) score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes

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