2022
DOI: 10.3389/fcvm.2022.961579
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The LAUsanne STAPHylococcus aureus ENdocarditis (LAUSTAPHEN) score: A prediction score to estimate initial risk for infective endocarditis in patients with S. aureus bacteremia

Abstract: IntroductionInfective endocarditis (IE) is a common complication of Staphylococcus aureus bacteremia (SAB). The study aimed to develop and validate a prediction score to determine IE risk among SAB.MethodsThis retrospective study included adults with SAB (2015–2021) and divided them into derivation and validation cohorts. Using the modified 2015 European Society of Cardiology modified Duke Criteria for definite IE, the LAUSTAPHEN score was compared to previous scores.ResultsAmong 821 SAB episodes, 419 and 402 … Show more

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Cited by 8 publications
(8 citation statements)
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“…However, it is important to note that the presence of these complications should not defer the search for IE in patients with bacteremia. These complications are accounted for in two prediction scores used to diagnose SAIE [ 8 , 19 ].…”
Section: Discussionmentioning
confidence: 99%
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“…However, it is important to note that the presence of these complications should not defer the search for IE in patients with bacteremia. These complications are accounted for in two prediction scores used to diagnose SAIE [ 8 , 19 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, they survived for at least 120 days, a timeframe deemed adequate for monitoring any recurrence of bacteremia in case of a misdiagnosis of the initial episode. Moreover, 2 of 3 cohorts included patients with IE or IE suspicion, resulting in a higher incidence of IE within the final cohort (36%) compared to previous studies (7%–14%) [ 8 , 19 , 20 ], potentially leading to selection bias. This overrepresentation of patients with a more severe phenotype could result in a false inflation of the sensitivity of a diagnostic test.…”
Section: Discussionmentioning
confidence: 99%
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“…Staphylococcus aureus is one of the most common causes of community and hospital-acquired bacteremias [ 1 ]. Due to its complexity, a holistic approach incorporating diagnostic workup (follow-up blood cultures, echocardiography, metastatic foci identification) and management (antimicrobial treatment and source control) is needed to improve outcome [ 2 4 ]. Despite such an approach, mortality remains high, ranging from 21 to 42% [ 5 10 ].…”
Section: Introductionmentioning
confidence: 99%