The Leydig Cell as a Target for Toxicants

Chen, Bing bing; Zirkin, Barry R.; Ge, Ren Shan

doi:10.1016/b978-0-08-046884-6.01108-8

Cited by 2 publications

(2 citation statements)

References 196 publications

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“…Although Siglec5 is considered a surface protein, the Leydig cells in the present study displayed strong immunoreactivity for Siglec5 in the nucleus. It is well known that Leydig cells stimulate spermatogenesis by secreting testosterone, a steroid hormone, which creates an environment that supports proper spermatogenesis development (Bing Chen et al, 2010; Sharpe et al, 1990). The synthesis and secretion of the testosterone is controlled by a network of intracellular and extracellular factors (Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Immunolocalization and expression of Siglec5 protein in the male reproductive tract of dromedary camel during rutting season

Khodair

Moqbel

Elseory

et al. 2023

Anat Histol Embryol

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Lectins are carbohydrate‐binding proteins that are highly selective for sugar groups on other molecules. Siglec5 is a cell‐surface lectin that belongs to the sialic acid‐binding Ig‐like lectins (Siglecs) and acts as a suppressor of immune responses. In this study, immunohistochemistry, western blotting and quantitative real‐time polymerase chain reaction (qRT‐PCR) were used to detect the expression of Siglec5 in the male reproductive tract of dromedary camels during the rutting season. Siglec5 displayed strong immunostaining in the cranial and caudal testicular regions and moderate immunostaining in the rete testis. Different parts of the epididymis showed varying immunoreactions to Siglec5. The spermatozoa in the testes and epididymis also showed positive immunostaining for Siglec5, whereas, the vas deferens showed negative immunostaining for the protein. The results obtained by western blotting confirmed the immunohistochemical detection of the protein in the testicular and epididymal tissues. The results of qRT‐PCR showed that Siglec mRNA was expressed differently in each part of the testis and epididymis; the highest levels of expression were observed in the caudal part of the testis and in the head of the epididymis. In conclusion, the present study revealed that Siglec5 is mainly located in the testis and epididymis, where sperm production and maturation occur. Therefore, this protein may play an essential role in the development, maturation and protection of camel sperm.

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Section: Discussionmentioning

confidence: 99%

“…an environment that supports proper spermatogenesis development (Bing Chen et al, 2010;Sharpe et al, 1990). The synthesis and secretion of the testosterone is controlled by a network of intracellular and extracellular factors (Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization and expression of Siglec5 protein in the male reproductive tract of dromedary camel during rutting season

Khodair

Moqbel

Elseory

et al. 2023

Anat Histol Embryol

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EFEK PEMBERIAN EKSTRAK RUMPUT KEBAR (Biophytum petersianum Klotzsch) TERHADAP JUMLAH SEL LEYDIG MENCIT (Mus musculus) JANTAN YANG DIPAPAR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

Nursadida

Plumeriastuti

Dhamayanti

et al. 2020

JBMV

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This study was aim to examine the effect of kebar grass extract (Biophytum petersianum Klotzsch) to against number leydig cells of mice (Mus musculus) by exposed 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Twenty five male mice (Mus musculus) 4 months with avarage body weight 20 g were used. These animals were divided into five groups (K(-), K(+), P1, P2 and P3). K(-) was treated with placebo, K(+) was treated by exposed TCCD single dose injection intaperitoneal 7µg/KgBw, P1 was treated by exposed TCCD single dose injection intaperitoneal 7µg/KgBw and kebar grass extract 0,045 mg/g Bw/day P2 was treated by exposed TCCD single dose injection intaperitoneal 7µg/KgBw and kebar grass extract 0,080 mg/g Bw/day, P3 was treated by exposed TCCD single dose injection intaperitoneal 7µg/KgBw and kebar grass extract 1,350 mg/g Bw/day. This research has been conducted for 53 days. The data were compared using ANOVA and Duncan test by SPSS 22.4 for windows. The result showed that Kebar Grass Extract in all of groups can prevent the damage of leydig cells in testis that exposed by TCCD significantly (p<0,05) and kebar grass extract 0,135 mg/kgBw/day can increase amount of leydig cells maximaly.

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The Leydig Cell as a Target for Toxicants

Cited by 2 publications

References 196 publications

Immunolocalization and expression of Siglec5 protein in the male reproductive tract of dromedary camel during rutting season

Immunolocalization and expression of Siglec5 protein in the male reproductive tract of dromedary camel during rutting season

EFEK PEMBERIAN EKSTRAK RUMPUT KEBAR (Biophytum petersianum Klotzsch) TERHADAP JUMLAH SEL LEYDIG MENCIT (Mus musculus) JANTAN YANG DIPAPAR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

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