The life-threatening eruption in HIV and immunosuppression

Malignant Syphilis as an Initial Presentation of HIV Infection: A Case Report

“…A treponemal infection may act as a facilitator or aggravator for HIV transmission from co-infected patients. 3 Co-infection of syphilis and HIV alters the course of both diseases. The clinical impact of HIV and syphilis coinfection is bidirectional; HIV alters the course of syphilis and syphilis also appears to adversely impact HIV disease progression and transmissibility.…”

“…Humoral and cellular immunity against Treponema pallidum depend on the stage of HIV infection and host defence; impairment in immunity may lead to changes in the clinical presentations and natural course of syphilis, increased number of syphilis lesion and degree of infectiousness, and shortened incubation time. A treponemal infection may act as a facilitator or aggravator for HIV transmission from co-infected patients 3 . Co-infection of syphilis and HIV alters the course of both diseases.…”

Cutaneous Manifestations of Sexually Transmitted Infections

“…Almost every PLWH will present with dermatological complaint at some point during their care. Compared with people living without HIV, PLWHs have a greater likelihood of skin eruptions because of dysregulation of the skin immune system or drug reactions (Ramos-e-Silva et al, 2020). A common skin condition that afflicts PLWHs is seborrheic dermatitis, which affects 30%–83% of patients (Adalsteinsson et al, 2020).…”

“…KS can present as violaceous macular, papular, or plaque lesions. KS affects the skin but can also involve other organs such as the lungs and gastrointestinal tract (Ramos-e-Silva et al, 2020). Recent research suggested that cumulative viral load level may trigger early development of KS independent of CD4 cell count; therefore, clinicians should be concerned of KS regardless of CD4 cell count and perform a thorough physical examination at every patient encounter (Dubrow et al, 2017).…”