The Limits of Pattern Recognition: Nodular Lung Disease in a Syrian Refugee

Lefkowitz, Rafael Y.; Mitma, Angel A; Altassan, Khaled Abdulrahman; Redlich, Carrie A.

doi:10.1513/annalsats.201702-163cc

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Silicotuberculosis is an important disease worldwide that needs specific attention [31], [32]. Some strategies can be implemented, including controlling or reducing exposure to silica dust, ensuring continuity of treatment of TB or extended anti-TB treatment, management of the situation by occupational health professionals, prevention of oscillating migration, providing workers with compensation, training and education in occupational health, improving the quality of life of miners and workers, intensive medical surveillance and TB screening in routine health check ups, and proper policy making to inhibit inhalation of dust by workers or employees, to decrease the rate of silicotuberculosis.…”

Section: Future Insights and Conclusionmentioning

confidence: 99%

Risk factors and control strategies for silicotuberculosis as an occupational disease

Shafiei

Ghasemian

Eslami

et al. 2019

New Microbes and New Infections

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Silicotuberculosis is critical in community settings among workers and employees exposed to silica dust. Older age of entry (>30 years), male sex, infection with human immunodeficiency virus (HIV), exposure duration, smoking, chronic obstructive pulmonary disease, migration, the severity of the silicosis and the intensity of the exposure are potential risk factors. Lack of timely diagnosis and treatment for tuberculosis (TB) may also raise the rate of infection; previous treatment of TB is possibly associated with the development of silicotuberculosis in more than half of patients, increasing with age (>40 years). Identification of risk factors benefits not only the academic research community, but also the workers or employees and policy making. Some strategies can be implemented, such as controlling or reducing exposure to silica dust, ensuring continuity of treatment of TB or extended anti-TB treatment, management of the situation by occupational health professionals, prevention of oscillating migration, providing workers with compensation, training and education in occupational health, improving the quality of life of miners and workers, intensive medical surveillance and TB screening in routine health check ups, and policy making for higher immunity to inhibit inhalation of dust by workers or employees.

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Section: Future Insights and Conclusionmentioning

confidence: 99%

Risk factors and control strategies for silicotuberculosis as an occupational disease

Shafiei

Ghasemian

Eslami

et al. 2019

New Microbes and New Infections

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“…The PubMed search included case reports written in English using the search terms 'lung silicotuberculosis' or 'lung silico-tuberculosis' or 'lung silicosis' and 'lung tuberculosis'. The search returned 64 results, of which 44 were excluded for reasons including an inaccessible report, non-tuberculosis infections, silicosis without tuberculosis, and formats other than case reports [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. The 20 included case reports described 26 relevant individual cases whose major findings are reported in Table 1.…”

mentioning

confidence: 99%

A Complex Case of Pulmonary Silico-Tuberculosis and Review of Literature

D’Sa,

Pezzuto,

Lunardi

et al. 2023

Diagnostics

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Silicosis caused by the inhalation/deposition of free silica particles is characterized by pulmonary inflammation/fibrosis. Among the clinical disorders associated with silicosis, tuberculosis is by far the most prominent. A 66-year-old male non-smoker, originally from North Africa, reported a dry cough and significant weight loss. He was a foundry worker. He had a medical history of bladder carcinoma associated with schistosomiasis. Computed tomography (CT) and positron emission tomography (PET)/CT showed bilateral multiple hypermetabolic lung nodules, some with cavitation. The patient underwent surgical resection of the largest nodule, which was highly suspicious of lung metastasis. The histological examination revealed multiple nodular formations. Several lesions showed the characteristic features of silicotic nodules. There were also adjacent well-formed granulomas, some with central caseous necrosis. A real-time polymerase chain reaction, performed for the identification and quantification of the DNA of the Mycobacterium tuberculosis complex, was positive. Pulmonary silico-tuberculosis is often encountered in patients with a history of silica exposure in tuberculosis-endemic areas. This case serves as a reminder to never underestimate patient occupational exposure and geographic origin. A careful histological diagnosis and molecular investigation are mandatory when approaching difficult cases, especially patients with a prior cancer history and clinical/radiological features suggestive of tumour recurrence/metastasis.

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