The link among microbiota, epigenetics, and disease development

El-Sayed, Amr; Aleya, Lotfi; Kamel, Mohamed S.

doi:10.1007/s11356-021-13862-1

Cited by 25 publications

(24 citation statements)

References 460 publications

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“…The consumption of high-carbohydrate low amino acid diet leads to the disturbance of Firmicutes-to-Bacteroidetes ratio. Restricted protein intake was also shown to change the gene expression pattern in the liver and reduce hepatic FXR-FGF15 signaling (Pak et al 2019;Holmes et al 2017;El-Sayed et al 2021). On the other hand, the consumption of low-fiber/high red meat diet alters the intestinal microbiota to favor tumor formation; diet rich in NSP enhances bacterial fermentation/utilization of ingested fibers and the production of short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate.…”

Section: Cancermentioning

confidence: 99%

“…Although E. coli is a normal commensal inhabitant in the human intestinal tract, some isolates acquired mobile genetic elements that harbor various virulence genes and become human pathogens (El Sayed 2000). One of these mobile genetic elements is the pathogenicity island polyketide synthases (pks), which encode colibactin, which is linked to the induction of IBD, Crohn's disease, and even CRC (Buc et al 2013;Bonnet et al 2014;Martin et al 2004).…”

Section: Cancermentioning

confidence: 99%

“…The second type is known as lysogenic phages that integrate their DNA in the bacterial genome and replicate passively with the bacteria. As bacteriophages are host-specific, they selectively infect and kill only susceptible bacterial species (El Sayed 2000). This may lead to a decrease in bacterial diversity and, therefore, indirectly induce certain human diseases such as IBD and even certain oral diseases (Norman et al 2015;Ly et al 2014).…”

Section: Role Of Virome In Health and Diseasesmentioning

confidence: 99%

“…On average, one gram of stool is estimated to contain at least 10 9 virus-like particles (VLPs) and 10 9 bacterial cells (Kim et al 2011). However, the microbiota composition is dynamic and undergoes continuous changes in response to external factors, including nutritional status, environmental factors, lifestyle, health status, and diseases, medications such as antibiotics (Table 2) (Scarpellini et al 2015;El-Sayed et al 2021). For example, the administration of high doses of antibiotics for 3 weeks leads to a dramatic reduction in the amounts of gut microbiome and fecal DNA content (Pak et al 2019).…”

Section: Introductionmentioning

confidence: 99%

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Microbiota’s role in health and diseases

El-Sayed

Aleya

Kamel

2021

Environ Sci Pollut Res

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The microbiome is a term that usually refers to the community of various microorganisms that inhabit/live inside human/animal bodies or on their skin. It forms a complex ecosystem that includes trillions of commensals, symbiotics, and even pathogenic microorganisms. The external environment, diet, and lifestyle are the major determinants influencing the microbiome's composition and vitality. Recent studies have indicated the tremendous influence of the microbiome on health and disease. Their number, constitution, variation, and viability are dynamic. All these elements are responsible for the induction, development, and treatment of many health disorders. Serious diseases such as cancer, metabolic disorders, cardiovascular diseases, and even psychological disorders such as schizophrenia are influenced directly or indirectly by microbiota. In addition, in the last few weeks, accumulating data about the link between COVID-19 and the microbiota were published. In the present work, the role of the microbiome in health and disease is discussed. A deep understanding of the exact role of microbiota in disease induction enables the prevention of diseases and the development of new therapeutic concepts for most diseases through the correction of diet and lifestyle. The present review brings together evidence from the most recent works and discusses suggested nutraceutical approaches for the management of COVID-19 pandemic.

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Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

Section: Role Of Virome In Health and Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microbiota’s role in health and diseases

El-Sayed

Aleya

Kamel

2021

Environ Sci Pollut Res

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“…In other words, they produced metabolites that could interact or provide substrates for methyl-transferase (DNA, and/or histone methylation/demethylation), HATs/HDACs for histone acetylation/deacetylation, etc. Various bacterial species among the members of the gut microbiota, depending on the microenvironmental conditions, have been proven to produce oncometabolite, immunomodulatory, "onco-reppressive," or metabolites that in turn epigenetic mechanisms [180][181][182][183][184][185][186].…”

Section: Epigenetic Modulations Nutrients Bioactive Food Compounds Microbiota and Cancermentioning

confidence: 99%

Reviewing cancer’s biology: an eclectic approach

Karidio

Şanlıer

2021

J Egypt Natl Canc Inst

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Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are commonly characterized by unrestricted cell proliferation and dysfunctional replicative senescence pathways. In fact, the cell cycle operates under the rigorous control of complex signaling pathways involving cyclins and cyclin-dependent kinases assumed to be specific to each phase of the cycle. At each of these checkpoints, the cell is checked essentially for its DNA integrity. Genetic defects observed in these molecules (i.e., cyclins, cyclin-dependent kinases) are common features of cancer cells. Nevertheless, each cancer is different concerning its molecular and cellular etiology. These could range from the genetic defects mechanisms and/or the environmental conditions favoring epigenetically harbored homeostasis driving tumorigenesis alongside with the intratumoral heterogeneity with respect to the model that the tumor follows. Conclusions This review is not meant to be an exhaustive interpretation of carcinogenesis but to summarize some basic features of the molecular etiology of cancer and the intratumoral heterogeneity models that eventually bolster anticancer drug resistance for a more efficient design of drug targeting the pitfalls of the models.

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Dose‐dependent effects of anthocyanin‐rich extracts on obesity‐induced inflammation and gut microbiota modulation

Vannuchi,

Jamar,

de Rosso

et al. 2024

BioFactors

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Obesity and its associated inflammatory state pose a significant health burden. Anthocyanins, bioactive compounds found in fruits and vegetables, have garnered interest in their potential to attenuate these conditions. Understanding the dose‐dependent response of anthocyanins is essential for optimizing their therapeutic potential in preventing and managing obesity. This comprehensive review explores the current knowledge on the dose‐dependent effects of anthocyanins on obesity in both human and animal models, analyzing the structure and mechanism of absorption of these compounds. The article also highlights the diverse mechanisms underlying anthocyanin action, the symbiosis between anthocyanins and gut microbiota impacting metabolite production, influencing diverse health outcomes, modulating cytokines, and activating anti‐inflammatory pathways. Additionally, their impact on energy metabolism and lipid regulation is discussed, highlighting potential contributions to weight management through AMPK and PPARγ pathways. Despite promising results, dose‐dependent effects are fundamental considerations, with some studies indicating less favorable outcomes at higher doses. Future research should focus on optimizing dosages, accounting for individual responses, and translating findings into effective clinical applications for obesity management.

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The link among microbiota, epigenetics, and disease development

Cited by 25 publications

References 460 publications

Microbiota’s role in health and diseases

Microbiota’s role in health and diseases

Reviewing cancer’s biology: an eclectic approach

Dose‐dependent effects of anthocyanin‐rich extracts on obesity‐induced inflammation and gut microbiota modulation

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