The link between otitis media with effusion and allergy: A potential role for intranasal corticosteroids

Lack, Gideon; Caulfield, Helen; Penagos, Martín

doi:10.1111/j.1399-3038.2010.01130.x

Cited by 59 publications

(40 citation statements)

References 43 publications

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“…Indoor allergens and respiratory allergies such as allergic rhinitis contribute to the onset of COM/ROM. The prevalence of atopic conditions, including allergic rhinitis in patients with COM/ROM ranges from 24% to 89% [41]. New evidence from cellular biology and immunology explained allergy as a cause for Eustachian tube (ET) obstruction [42].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic and Recurrent Otitis Media–A Meta-Analysis

et al. 2014

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Risk factors associated with chronic otitis media (COM) and recurrent otitis media (ROM) have been investigated in previous studies. The objective of this study was to integrate the findings and determine the possible risk factors for COM/ROM based on our meta-analysis. A comprehensive search of electronic bibliographic databases (PubMed, Embase, CNKI and Wanfang database) from 1964 to Dec 2012, as well as a manual search of references of articles, was performed. A total of 2971 articles were searched, and 198 full-text articles were assessed for eligibility; 24 studies were eligible for this meta-analysis. Regarding risk factors for COM/ROM, there were two to nine different studies from which the odds ratios (ORs) could be pooled. The presence of allergy or atopy increased the risk of COM/ROM (OR, 1.36; 95% CI, 1.13–1.64; P = 0.001). An upper respiratory tract infection (URTI) significantly increased the risk of COM/ROM (OR, 6.59; 95% CI, 3.13–13.89; P<0.00001). Snoring appeared to be a significant risk factor for COM/ROM (OR, 1.96; 95% CI, 1.78–2.16; P<0.00001). A patient history of acute otitis media (AOM)/ROM increased the risk of COM/ROM (OR, 11.13; 95% CI, 1.06–116.44; P = 0.04). Passive smoke significantly increased the risk of COM/ROM (OR, 1.39; 95% CI, 1.02–1.89 P = 0.04). Low social status appeared to be a risk factor for COM/ROM (OR, 3.82; 95% CI, 1.11–13.15; P = 0.03). Our meta-analysis identified reliable conclusions that allergy/atopy, URTI, snoring, previous history of AOM/ROM, Second-hand smoke and low social status are important risk factors for COM/ROM. Other unidentified risk factors need to be identified in further studies with critical criteria.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Chronic and Recurrent Otitis Media–A Meta-Analysis

et al. 2014

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“…Many risk factors have been associated with this disease: young age (6,7) lack of breast feeding (6,8,9) low mother education, (9)(10)(11) low socioeconomic status (6,10) day care attendance (8,11) parental smoking, (6,11,12) upper respiratory tract infections (6,9,11) allergy (6,9,11,13,14) and snoring. (6,9) Although it is a self-limiting condition in the majority of cases, OME may become chronic to the extent that it affects child education and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Otitis Media with Effusion in School Children in Qassim Region of Saudi Arabia

Alhumaid¹,

Abou-Halawa²

2014

IJHS

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Abstract:Objective: To determine the prevalence of otitis media with effusion (OME) among school children in Qassim region of Kingdom of Saudi Arabia and to determine relevant risk factors in affected children. Methods:Through a cross-sectional study, 1488 children in the age range 6-12 years were randomly selected from 25 primary schools in Qassim region. A questionnaire was used to determine risk factors for OME. Otoscopy and tympanometry were used to diagnose and confirm OME. Pure tone average for children with confirmed OME was measured. Teachers of children were asked to complete a questionnaire evaluating child's level of school performance. Results:Prevalence of OME in the study population was 7.5% (112/1488). In univariate analysis, it was strongly associated with age less than 8 years (p< 0.0001; OR= 4.23, 95% CI: 2.85-6.29 ), family size more than 4 members in the household((p<0.0001; OR= 4.45, 95% CI: 2.23-8.88), mother education less than secondary school education (p<0.0001; OR=2.2, 95% CI: 1.47-3.29), recurrent acute otitis media (AOM) (p<0.0001; OR=5.73, 95% CI: 3.47-9.45), and hearing loss symptom (p< 0.0001; OR= 3.39, 95% CI: 1.92-5.99). It is less strongly associated with history of preschool AOM (p= 0.002; OR= 3.15, 95% CI: 1.67-5.97), nasal discharge (p= 0.003; OR= 1.91, 95% CI: 1.24-2.93) and snoring (p=0.03; OR= 1.76, 95% CI: 1.06-2.94). OME was significantly higher in schools located in rural districts (p<0.001, OR= 2.82, 95% CI: 1.86 -4.28). In multivariate regression model, five of these factors were found to be predictors of OME: age less than 8 years (OR= 5.052, 95% CI:3.289-7.762), family size more than4 members in the household) (OR= 4.192, 95% CI: 2.033-8.643), rural school district (OR=3.037, 95% CI: 1.933-4.772), mother education lower than secondary school education) (OR=2.041, 95% CI:1.602-3.877) and recurrent AOM (OR=4.914, 95% CI: 2.677-9.02). Children with OME tend to have poorer school performance compared to normal children (p=0.067). No significant correlation was found between OME and type of feeding during the first two years of life (p=0.62; OR= 0.87, 95% CI: 0.51-1.49), preschool daycare attendance (p=0.17; OR= 0.71, 95% CI: 0.44-1.16), home exposure to cigarette smoke (p=0.4; OR= 1.34, 95% CI:0.68 -2.65), visits to ENT clinic (p=0.13; OR= 0.58, 95% CI:0.29-1.18), and ENT operations (p=0.12; OR= 0.46, 95% CI: 0.17-1.27). Conclusion:Prevalence of OME in Qassim region reaches 7.5% in school children. Age less than 8 years, family size more than 4 members in the household, mother education less than secondary school education, living in rural area and recurrent AOM are found to be predictors of OME in Qassim region. In this population of children, otoscopy and tympanometry should be used as screening tools for OME.

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“…Recent otolaryngology literature has also explored the role of allergies as the underlying cause of multiple aerodigestive disease. 27,28 Limitations This study can only be considered a pilot study as it was performed in a cohort whom CMPA was diagnosed and had positive response to elimination with respect to their gastrointestinal manifestations. Future clinical studies confirming the validity of the questionnaire in patients not previously diagnosed with CMPA will be needed.…”

Section: Discussionmentioning

confidence: 99%