The Link Between Plasma 25-Hydroxyvitamin D and Lung Function in General and Asthmatic Children

KhanSara,; MaiXiao-Mei,; ChenYue,

doi:10.1089/ped.2013.0312

Cited by 4 publications

(7 citation statements)

References 29 publications

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“…In general agreement with our results, that study showed that the inverse association between vitamin D deficiency and lung function was more pronounced among adults who were non-smokers and did not use inhaled corticosteroids 14 . In contrast to our results, serum or plasma 25(OH)D was not associated with lung function in a Danish population-based study of 4999 adults 15 or in a Canadian Health Measure Survey that included 1,421 children 41 . Moreover, the VIDA (Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma) trial found no significant effects of vitamin D on lung function (a secondary outcome) in adults with persistent asthma and vitamin D insufficiency 19 .…”

Section: Discussioncontrasting

confidence: 99%

Vitamin D Insufficiency and Asthma in a US Nationwide Study

Han

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Celedón

2017

The Journal of Allergy and Clinical Immunology: In Practice

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Background Vitamin D insufficiency (a serum 25(OH)D < 30 ng/ml) has been associated with asthma morbidity. Objective To examine vitamin D insufficiency, asthma and lung function among U.S. children and adults. Methods Using data from NHANES for 2001–2010, we examined vitamin D insufficiency and: 1) current asthma or wheeze in 10,860 children (6–17 years) and 24,115 adults (18–79 years), and 2) lung function in a subset of participants. Logistic or linear regression was used for the multivariable analysis, adjusting for age, gender, race/ethnicity, income, body mass index, smoking, and C-reactive protein level. Results Vitamin D insufficiency was associated with current asthma (odds ratio [OR]=1.35, 95% confidence interval [CI]=1.11–1.64) and current wheeze in children, as well as with current wheeze in adults (OR=1.17, 95%CI=1.04–1.31). After stratifying the analysis by race/ethnicity and (in adults) current smoking, vitamin D insufficiency was associated with current asthma and wheeze in non-Hispanic white children only; in adults, vitamin D insufficiency was associated with current wheeze in non-Hispanic whites and blacks. Vitamin D insufficiency was also associated with lower FEV1 and FVC in children and adults. When analyzing each NHANES wave separately, vitamin D insufficiency prevalence was 72%–76% from 2001 to 2006, and then decreased from 2007 to 2010 (64%–65%); interestingly, asthma prevalence decreased for the first time from 2007–2008 (8.2%) to 2009–2010 (7.4%). Conclusions We show racial/ethnic-specific associations between vitamin D insufficiency and current asthma or wheeze in children and adults. Moreover, we report parallel recent decrements in the prevalence of vitamin D insufficiency and asthma.

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Section: Discussioncontrasting

confidence: 99%

Vitamin D Insufficiency and Asthma in a US Nationwide Study

Han

Forno

Celedón

2017

The Journal of Allergy and Clinical Immunology: In Practice

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“…Regarding a sex difference, a most recent report in children provided consistent results of an association between low plasma 25(OH)D levels and low FEV1 and FEV1/FVC ratio in boys with asthma [25]. A study of 3359 Canadian adults observed an association between vitamin D deficiency (<50 nmol·L…”

Section: Discussionmentioning

confidence: 86%

Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

et al. 2014

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The association between vitamin D status and lung function in adults with asthma remains unclear.We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19-55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L −1 was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals.44% of asthma adults had serum 25(OH)D levels <50 nmol·L −1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis ( p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L −1 was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L −1 was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%-−0.25%).Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis. @ERSpublications Low 25(OH)D levels were not associated with airway obstruction in most asthma adults except for men with no allergy

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“…Based on the inclusion and exclusion criteria, a total of 35 studies were finally included in our meta-analysis. Among them, 24 studies were analyzing the association between 2, 5-OHD level and the occurrence of asthma (Alyasin et al, 2011;Awasthi & Vikram, 2014;Bai & Dai, 2018;Bener et al, 2014;Chinellato et al, 2011;Esfandiar et al, 2016;Han et al, 2017;Han et al, 2018;Hatami et al, 2014;Havan et al, 2017;Hennessy et al, 2018;Kang et al, 2018;Khan et al, 2014;Kim et al, 2017;Menon et al, 2012;Mirzakhani et al, 2018;Munkhbayarlakh et al, 2019;Omole et al, 2018;Ozkars et al, 2019;Ozturk Thomas et al, 2019;Pollard et al, 2017;Reinehr et al, 2018;Thorsteinsdottir et al, 2020;Wawrzyniak et al, 2017), and 12 studies were evaluating the effect of vitamin D supplement in treating asthma (Bar Yoseph et al, 2015;Baris et al, 2014;Jensen et al, 2016;Kang et al, 2018;C. P. Kerley et al, 2016;Litonjua et al, 2020;Paweł Majak et al, 2011;P.…”

Section: Literature Selectionmentioning

confidence: 99%