This article presents the results of a study focused on collaboratively developing an Innovation Management Model (MGI) for the leather agro-industrial chain in Colombia. This study integrates the participation of interested parties, the prioritization of variables, the literature review, and the validation of the model, emphasizing sustainability considerations throughout the process. The methodology involved a literature review, using Scopus and Google Scholar, focusing on innovation management models, open innovation, and sustainability of the leather sector. In addition, three surveys were conducted to prioritize the established variables, using Likert scale questions, to assess relevance and congruence. Key findings included 26 critical variables covering aspects such as agricultural and technological innovation in platforms and projects, capacity development, R&D activities, supply chain dynamics, innovation management processes, knowledge and technology integration, business model adaptation for sustainable development, and environmental impact assessment. The prioritized innovation model aims to guide stakeholders to define open innovation strategies, sustainable and regenerative innovation generation, and improvement of strategic and technological capabilities.