The liver regenerative response elicited by antisecretory agents in partially hepatectomized rats: A comparison between omeprazole and famotidine

Abstract

Liver regeneration after omeprazole (OMP) or famotidine (FAM) administration was examined in 66% hepatectomized rats. The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4 mg/kg per day for 3 or 7 days suppressed LRR and MI 3 and 7 days after hepatectomy. However, the administration of FAM 0.8 mg/kg per day for 3 or 7 days did not change either LRR or MI. Increased gastrin levels in the blood were seen only after OMP administration. The food intake was unchanged by OMP or FAM, but FAM increased water intake. The liver functional score, glutamic pyruvic transaminase and alkaline phosphatase in the blood all increased with OMP, but FAM had no apparent effect on the hepatic or renal function. These observations suggest that a large dosage of OMP suppresses liver regeneration, while FAM appears to have no meaningful effect on regeneration.

Efeito do omeprazol e do pantoprazol sobre a regeneração hepática após hepatectomia parcial em ratos

“…Ambas são inibidoras da bomba de prótons (H+, K+-ATPase) e atuam na redução da secreção gástrica 4 . Por isso, são bastante usadas profilaticamente no período pós-operatório de ressecções hepáticas para aliviar o stress cirúrgico e evitar a formação de úlceras e, conseqüentemente, sangramento 5 . , o omeprazol, aplicado durante 3 dias após a hepatectomia, estimulou a regeneração hepáti-ca com 0,2 mg/Kg ao dia e a inibiu com 0,4 mg/Kg ao dia.…”

“…Várias drogas, entre elas omeprazol e pantoprazol, são usadas para tratar essas úlceras e, profilaticamente, para evitar sua formação 3,4 . Alguns estudos mostraram que o omeprazol, a depender da concentração, tanto pode inibir quanto estimular a regeneração do fígado 5,6 . Quanto ao efeito do pantoprazol, nenhum estudo foi encontrado.…”

“…Alguns estudos mostraram que o omeprazol, a depender da concentração, tanto pode inibir quanto estimular a regeneração do fígado 5,6 . Quanto ao efeito do pantoprazol, nenhum estudo foi encontrado.…”

Effect of Proton Pump Inhibitors on Hepatic Regeneration

“…One study reports negative effects [20] , whereas the lack of any effect [23] and positive effects [24] have been reported in others. De Melo et al [20] also reported in their experimental study that pantoprazole has no effect on liver regeneration.…”

“…Aono [23] reported that omeprazole constrains liver regeneration and increases the level of transaminases in 66% of hepatectomy models performed on rats. In contrast, Ohtake et al [24] reported that following partial hepatectomy of rats, liver regeneration was stimulated, the cytotoxic effect of omeprazole was not observed, and the mitotic index of omeprozole-treated rats on the 3rd day was significantly increased compared to the control group.…”