2019
DOI: 10.1016/j.devcel.2019.03.003
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The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

Abstract: Highlights d lep-5 acts in the heterochronic pathway to promote the larvalto-adult transition d lep-5 is a 600 nt, highly structured lncRNA that is conserved across Caenorhabditis d Like the Makorin LEP-2, lep-5 promotes the degradation of LIN-28 protein d lep-5 may act as a scaffold to bring LEP-2 into close proximity with LIN-28

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Cited by 16 publications
(27 citation statements)
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References 105 publications
(164 reference statements)
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“…
10.7554/eLife.43660.006Figure 2—figure supplement 1.Structural features of the lep-5 lncRNA required for its function in the nervous system.( A ) A predicted model for lep-5 secondary structure; see Kiontke et al, 2019 for details. Colored shading indicates regions disrupted by the mutants tested.
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Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…
10.7554/eLife.43660.006Figure 2—figure supplement 1.Structural features of the lep-5 lncRNA required for its function in the nervous system.( A ) A predicted model for lep-5 secondary structure; see Kiontke et al, 2019 for details. Colored shading indicates regions disrupted by the mutants tested.
…”
Section: Resultsmentioning
confidence: 99%
“…( C ) The fs21 allele mutates six nucleotides (shown in red) important for the predicted zipper ‘a’ region. The fs21 fs25 allele mutates an additional seven positions ~ 325 nt in the 3´ direction in a manner predicted to allow zipper ‘a’ to re-form, even in the presence of significant changes in its primary sequence (Kiontke et al, 2019). 10.7554/eLife.43660.007Source data for Figure 2—figure supplement 1.…”
Section: Resultsmentioning
confidence: 99%
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“…LncRNAs can regulate development and sexual maturation. Lep-5 , a 600 nt cytoplasmic lincRNA, regulates developmental timing as a scaffold to bring LEP-2 into its target gene LIN-28, and takes part in tail tip morphogenesis of males regulating sexual maturation cell-autonomously in nervous system [ 67 , 68 ]. Lep-5 is conserved across Caenorhabdit is uncovering evidence for its function in evolution [ 67 , 68 ].…”
Section: The Physiological Functions Of Lncrna In Animalsmentioning
confidence: 99%